中国汉族群体D4S111位点的遗传多态性研究  

POLYMORPHISM ANALYSIS OF THE D4S111 LOCUS IN A CHINESE HAN POPULATION

作　　者：光炜[1] 郭奕斌[1] 林群娣[1] 杜传书[1] 

机构地区：[1]中山医科大学医学遗传学研究室

出　　处：《中山医科大学学报》1998年第4期255-257,共3页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：美国中华医学基金会(CMB)资助

摘　　要：目的：研究中国汉族群体中α艾杜糖苷酶基因Ｄ４Ｓ１１１位点的遗传多态性。方法：采用扩增片段长度多态性（ＡｍｐＦＬＰ）分析技术，检测了广州地区汉族无血缘关系健康个体９７名。结果：Ｄ４Ｓ１１１位点，在９７名无关个体中发现５个等位基因和９种基因型，等位基因片段长度为８３０～５１０ｂｐ，基因频率为０００５２～０３６０８，ＰＩＣ为０５９６６，杂合性为０７８。结论：中国汉族群体中Ｄ４Ｓ１１１位点具有高度多态性，并与其它种族间存在差异性。Objective: To investigate the genetic polymorphism of the locus (D4S111) in Chinese Han population that contains a variable number of tandem repeat (VNTR) within α L iduronidase gene. Method: 97 unrelated healthy individuals of Han population were analyzed using amplified fragment length polymorphism(Amp FLP). Results: Five alleles ranging from 830 to 510 bp in size and nine different genotypes were observed. The allele frequencies were 0 0052 to 0 3608. The PIC of D4S111 locus was 0 5966, and the heterozygosity was 0 78. Conclusion: The polymorphism of D4S111 locus in Chinese Han population was high and different from those in other populations.

关 键 词：中国汉族 艾杜糖醛酸酶 多态性 限制性片段长度 

分 类 号：Q986[生物学—人类学] Q346.5