性激素与中成药治疗对绝经早期妇女生存质量的影响及其成本效用分析  

Sexual hormone and traditional Chinese patent medicine for early postmenopausal women:effect on quality of life and cost-utility analysis

作　　者：周玲玲[1] 许良智[1] 刘宏伟[1] 张静 刘颖[1] 刘晓芳[1] 唐柳林[1] 庄静[1] 刘小先[1] 乔林[1] 

机构地区：[1]四川大学华西第二医院妇产科,四川成都610041

出　　处：《南方医科大学学报》2009年第11期2182-2186,共5页Journal of Southern Medical University

基　　金：国家十五科技攻关课题(2004BA720A08);四川省人事厅四川省学术和技术带头人培养基金重点项目(06SXS-06)

摘　　要：目的评价倍美力和坤泰胶囊对绝经早期妇女生存质量的影响,并进行成本效用分析。方法将绝经早期的绝经后综合征患者随机分为低剂量倍美力组(0.3mg/d与0.6mg/d交替使用,n=29)和坤泰组(4g/d,n=28),疗程1年,每3个月随访一次,评价绝经期生存质量,并采用等级尺度法提取效用值以进行成本效用分析。结果两组间治疗后各时间点的生存质量评分均无差异(P>0.05);而各组内的生存质量在治疗1年后均较治疗前升高(P<0.05),但坤泰起效晚于倍美力;倍美力组和坤泰组的质量调整生命年的成本分别为13581.45元/年和25105.12元/年。增量成本效用分析和敏感性分析表明坤泰组的花费高于倍美力组。符合方案集分析与意向性分析的结果一致。结论低剂量倍美力和中成药坤泰均可有效改善绝经早期的绝经后综合征患者的生存质量;但1年内服用坤泰成本较高。Objective To evaluate the effect of Premarin and Kuntai capsule（a traditional Chinese patent medicine） on the quality of life（QOL） and their cost-utility in early postmenopausal women.Methods Fifty-seven women with menopausal syndrome in the early postmenopausal stage were randomly allocated into Premarin group（0.3 mg/day and 0.6 mg/day alternately,n=29） and Kuntai group（4 g/day,n=28）.The therapies lasted for one year and the patients were followed up every 3 months.The QOL of the patients was evaluated and the utility scores were obtained from rating scale to conduct a cost-utility analysis（CUA）.Results At each follow-up examination,no significant difference was found in the QOL between the two groups（P〉0.05）.The QOL obviously increased after the 1-year-long therapy in both the groups,and Kuntai required longer treatment time than Premarin to take effect.The cost-utility ratio of Premarin and Kuntai were 13581.45 yuan/QALY（quality adjusted life year） and 25105.12 yuan/QALY,respectively.Both incremental cost analysis and sensitivity analysis showed that Kuntai was more costly than Premarin.The result of per-protocol analysis was consistent with that of intention-to-treat analysis.Conclusion At early stage of menopause,the QOL of women with menopausal syndrome can be significantly improved by low-dose Premarin and Kuntai capsule,but the latter is more costly.

关 键 词：绝经早期 倍美力 坤泰胶囊 生存质量 成本效用分析 

分 类 号：R711.75[医药卫生—妇产科学]