连续心指数监测在急性心力衰竭模型建立中的应用  

Application of continuous cardiac index monitoring in acute heart failure model

作　　者：周健[1] 吴晓云[1] 韩晨俊[1] 李洲斌[1] 臧旺福[1] 

机构地区：[1]上海交通大学医学院瑞金医院心脏外科,上海200025

出　　处：《上海交通大学学报（医学版）》2009年第11期1341-1343,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委重点科技攻关项目(09441901300)~~

摘　　要：目的建立猪急性心力衰竭的外科实验模型,采用连续心指数(CCI)监测评价心功能状态。方法采用冠状动脉结扎法尝试建立猪(n=6)急性心力衰竭模型。使用Swan-Ganz导管及Vigilance监护仪获取CCI,结合血流动力学、生化及心脏超声等指标评价心功能。结果5只动物成功建模。与基础状态比较,急性心力衰竭状态下动物的平均动脉压(MAP)、肺动脉收缩压(PASP)、混合静脉氧饱和度(SVO2)等血流动力学指标和CCI均发生具有统计学意义的变化(P<0.05);血生化指标未见明显改变;左心室射血分数(LVEF)明显下降(P<0.05)。结论运用CCI监测和评价动物模型的心功能状态是可行的。以冠状动脉结扎法制备的猪急性心力衰竭模型,基本可满足外科实验研究的需要。Objective To establish the swine acute heart failure model for surgical experiment,and evaluate the heart function by continuous cardiac index （CCI）. Methods Swine heart failure model was attempted to establish by coronary ligation in six swines. CCI was obtained by Swan-Ganz catheters and Vigilance monitor,and hemodynamic,biochemical and ultrasonocardiographic results were utilized to evaluate the changes of heart function. Results Five swines accomplished the experiment. Compared with basic status,there were significant differences in mean arterial pressure （MAP）,pulmonary artery systolic pressure （PASP）,mixed venous oxygen saturation （SVO 2） and CCI for swines with heart failure （ P 0.05）,there was no significant change in biochemical parameters,while left ventricle ejection fraction （LVEF） significantly decreased （ P 0.05）. Conclusion CCI is feasible in monitoring and evaluating heart function of animal model. The swine acute heart failure model established by coronary ligations can meet the needs of surgical experiment in principle.

关 键 词：连续心指数 动物模型 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]