淫羊藿在MSCs成脂分化过程中对PPAR γ基因表达影响的实验研究进展  

Experimental research on the effects of epimedium on expression of PPAR γ gene in the progress of the MSCs adipogenic differentiation

作　　者：刘海全[1] 秦佳佳[2] 杨海韵[1] 刘庆思[3] 

机构地区：[1]广东佛山市中医院,佛山528000 [2]暨南大学 [3]广州中医药大学

出　　处：《中国骨质疏松杂志》2009年第11期868-870,共3页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金资助项目(项目编号:30901915);中国博士后科学基金面上资助项目(项目编号:20080440744)

摘　　要：骨髓基质干细胞具有多向分化的能力,研究发现其成脂分化与骨质疏松症存在着不可忽视的关系。PPAR γ是脂肪分化的主要调控因子,已有研究发现其对MSCs分化方向起关键性调控作用。淫羊藿对MSCs成骨分化具有促进作用,但其在MSCs成脂分化过程中对PPAR γ基因表达影响目前尚无研究报道。MSCs has capacity of multi-directional differentiation. Some study found there was inevitable relationship between MSCs＇s adipogenic and Osteoporosis. PPAR γ is the main control factor of the adipose differentiation. It has been found playing a crucial role in the differentiation of MSCs. Epimedium can promote the osteogenic differentiation of MSCs. But there is not any report about its impact on the PPAR γ gene expression during MSCs adipogenic differentiation.

关 键 词：淫羊藿 成脂分化 骨质疏松 研究进展 

分 类 号：R274.9[医药卫生—中西医结合]