墨旱莲化学成分及药理活性的初步研究  

Preliminary Studies on Chemical Constituents and Pharmacological Action of Eclipta prostrata L.

作　　者：韩英[1] 夏超[1] 陈小媛 向仁德[1] 刘桦[2] 闫清 许德义[2] 

机构地区：[1]江苏省药物研究所植化室 [2]南京铁道医学院药理室

出　　处：《中国中药杂志》1998年第11期680-682,共3页China Journal of Chinese Materia Medica

摘　　要：目的：中药墨旱莲植物抗肝炎活性成分的研究。方法：醇提、硅胶柱层板法分离及药理活性筛选。结果：分离得到４个化合物，经光谱学分析鉴定了其中２个化合物，分别为豆甾醇（ｓｔｉｇｍａｓｔｅｒｏｌ，Ⅰ）和α三噻吩（αｔｅｒｔｈｉｅｎｙｌ，Ⅱ）。结论：化合物Ⅱ为首次从该植物中分得，。初步药理实验表明。Objective:To study the pharmacologically active components of Eclipta prostrata.Method:The components were extracted by alcohol and isolated by silica gel column and subjected to pharmacological screening.Result:Four compounds were isolated from E.prostrata, of which two were identified as stigmasterol and α terthienyl. Conclusion:α Terthienyl was isolated from the plant for the first time.The EtOAc part of alcoholic extraction exhibits significant hepatoprotective activity against carbon terachloride induced liver injury in rats.

关 键 词：墨旱莲 化学成分 药理 中药 

分 类 号：R284.1[医药卫生—中药学] R282.710.5[医药卫生—中医学]