胎膜早破发生率及对胎儿健康危害的调查研究  

An investigation of impacts of premature rupture of membranes on fetal health

作　　者：于亚滨[1] 刘敬[2] 吴静[2] 黄俊锦[2] 张莉[1] 

机构地区：[1]首都医科大学附属北京妇产医院,北京100026 [2]北京军区总医院附属八一儿童医院,北京100700

出　　处：《中国妇幼健康研究》2009年第6期619-621,共3页Chinese Journal of Woman and Child Health Research

基　　金：中国博士后科学基金面上资助项目（20080431405）;中国博士后科学基金特别资助项目（200801041）致谢：北京市海淀妇幼保健院张雪峰主任、湖北省妇幼保健院夏世文主任、河北省秦皇岛市妇幼保健院秦桂莲主任、江苏省镇江市妇幼保健院卢红艳主任分别提供了各自所在医院近年有关分娩量及PROM发生情况等方面的资料,在此一并表示感谢.

摘　　要：目的在调查胎膜早破发生率的基础上，探讨胎膜早破可能对胎儿造成的不利影响。方法回顾性调查2003年1同．2007年12月5年间在北京妇产医院等6家医院每年的分娩总数及胎膜早破例数，计算胎膜早破发生率；计算各医院胎膜早破组与无胎膜早破组在早产发生率方面的差异；统计与胎膜早破相关的胎儿疾病及围产儿死亡等情况。结果调查结果显示，胎膜早破的发生率为19．53％；胎膜早破组与无胎膜早破组比较，胎儿宫内窘迫的发生率分别为14．02％和6．71％，新生儿窒息的发生率分别为15．00％和7．63％，早产发生率分别为11．20％和5．96％，围产儿病死率分别为15．47‰和7．28‰，经比较差异均具有统计学意义（χ^分别为32．26、34．56、994．62、4．15，均P〈0．05）。结论胎膜早破是孕产妇常见并发症，胎膜早破严重地危害了胎儿的健康，显著增加了围产期合并症的发生率及新生儿死亡率。Objective To investigate impacts of premature rupture of membranes （PROM） on fetal health. Methods The data of pregnant women from 5 special hospitals and one general hospital in China's Mainland over a 5 period from Jan. , 2003 to Dee. , 2007 were investigated retrospectively. The total incidence rate of PROM and differences in incidence rate of premature delivery between PROM group and non-PROM group in each hospital were caculated. The fetal diseases and mortality of perinatal infants associated with PROM were investigated. Results The incidence rate of PROM was 19.53%. The incidence rate of fetal distress was 14.02% in PROM group and 6.71% in non-PROM group, the incidence rate of neonatal asphyxia was 15.00% in the PROM group and 7.63% in the non-PROM group, the incidence rate of premature labor was 11.20% in the PROM group and 5.96% in the non-PROM group, the incidence rate of perinatal mortality was 15.47%v in the PROM group and 7.28%o in the non-PROM group, and there were all significant differences between the two groups （χ^2 = 32.26, 34.56,994.62, 4.15 respectively, all P 〈 0.05 ）. Conclusion PROM is a common pregnancy complication. It could affect many aspects of health of fetus seriously and increase incidence of perinatal complications and neonatal mortality rate.

关 键 词：胎膜早破 发生率 胎儿健康 流行病学调查 

分 类 号：R714.43[医药卫生—妇产科学]