雄激素与Nogo蛋白对神经系统发育的作用  

Effects of androgen and Nogo on development of nervous system

作　　者：张媛 李占魁 

机构地区：[1]西安兵器工业521医院新生儿科,陕西西安710065 [2]陕西省妇幼保健院新生儿科,陕西西安710004

出　　处：《中国妇幼健康研究》2009年第6期736-739,共4页Chinese Journal of Woman and Child Health Research

基　　金：国家自然科学基金资助项目（30471827）

摘　　要：雄激素是近年来研究较多的具有神经保护作用的类固醇激素，可以调节神经营养因子含量，抗氧化损伤及促进神经细胞轴突再生，对于中枢神经系统损伤性疾病具有潜在治疗作用。Nogo是近年来人们在中枢神经系统髓磷脂中研究发现的一种抑制轴突生长的蛋白，与中枢神经再生抑制密切相关。目前已证实Nogo蛋白在体外培养时有很强的轴突生长抑制活性。研究雄激素与Nogo蛋白对中枢神经系统的作用及其之间的相互关系，对于治疗中枢神经系统损伤性疾病，具有重要的指导作用。Androgen is a kind of steroid hormone which has neuroprotective action. It can regulate content of neurotrophic factors, prevent oxidative damage and promote regeneration of axon. So, it has potential therapeutic effect for nerve injury diseases in central nervous system （CNS）. Nogo is a kind of protein that can inhibit axon growth found in myelin of CNS and has a close correlation with anti-regeneration of central nerves. It has been proven that Nogo has strong axon growth inhibitory activity when it was cultivated in vitro. The study on effects of androgen and Nogo on CNS and their interactions is of important instructive significance for treatment of injury diseases in CNS.

关 键 词：雄激素 轴索过度生长抑制因子 中枢神经系统 缺氧缺血性脑损伤 

分 类 号：R722[医药卫生—儿科]