1型糖尿病青春期女性的卵巢功能  

Ovarian function of pubertal women with type 1 diabetes meilitus

作　　者：王秀秀[1] 李威[1] 匡洪影[1] 吴效科[1] 

机构地区：[1]黑龙江中医药大学附属第一医院妇产科,黑龙江哈尔滨150040

出　　处：《中国妇幼健康研究》2009年第6期748-750,共3页Chinese Journal of Woman and Child Health Research

基　　金：科技部国家“十一五”科技支撑计划资助项目（2007BA1208015）

摘　　要：胰岛素对碳水化舍物代谢方面的作用众所周知，其对调节卵巢功能同样起着很重要的作用。卵巢卵泡膜细胞、颗粒细胞和间质细胞可能受到胰岛素缺陷或胰岛素过多的影响，其可能出现在1型糖尿病女性中。即使积极应用胰岛素进行治疗，在1型糖尿病女性中仍会被观察到乳房初发育、阴毛初现和月经初潮的年龄有所延迟。另外，卵巢高雄激素血症可能在青春晚期出现，多毛和多囊卵巢综合征在1型糖尿病成年女性中发生率有所增加。这些内分泌异常可能与非生理性的胰岛素替代治疗和高血糖水平有关。该文对1型糖尿病青春期女性发育和生殖方面的异常进行了综述，揭示了临床上青春期延迟、月经紊乱和高雄激素血症等可能最终导致一些患者成年后出现多囊卵巢综合征的重要问题。The effect of insulin on carbohydrate metabolism is well known. Also, the hormone plays an important role in regulating ovarian function. Granular cells, theca ceils and stromal cells in ovaries may be affected by insulin deficiency or excess, which may be present in women with type 1 diabetes mellitus （TI D）. Recent researches have shown that even though intensive insulin therapy, some delays in ages of thelarche, pubarche and menarche still can be observed in those girls with T1D. In addition, ovarian hyperandrogenism may occur during late adolescence and an increased prevalence of hirsutism and polycystic ovarian syndrome （PCOS） may be seen in aduh women with T1 D. These endocrine abnormalities may be related to non-physiological insulin replacement therapy and hyperglycemia. This paper reviwed abnormalities in pubertal development and reproduction observed in girls with type 1 diabetes mellitus, and revealed several significant clinical problems such as pubertal delay, menstrual disturbances and hyperandrogenism which may ultimately lead to development of PCOS in adulthood of some of these patients.

关 键 词：青春期 胰岛素 1型糖尿病 多囊卵巢综合征 高雄激素血症 

分 类 号：R587.1[医药卫生—内分泌]