Synthesis of novel biodegradable poly(ethylene glycol) analogue:Water-soluble aliphatic polyester with pendant oligo(ethylene glycol) chains  

作　　者：Lei Feng Jian Yuan Hao Cheng Dong Xiong Xian Mo Deng 

机构地区：[1]Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, P.O. Box 415, Chengdu 610041, China [2]School of Microeletronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China [3]Graduate School of Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Chinese Chemical Letters》2009年第12期1502-1505,共4页中国化学快报（英文版）

基　　金：supported by the National Natural Sciences Fund of China(No.50603025);the Opening Project of State Key Laboratory of Polymer Materials Engineering(Sichuan University).

摘　　要：A novel poly（ethylene glycol） （PEG） analogue composed of aliphatic polyester backbone and pendant oligo（ethylene glycol） short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-（（2-（2-metho xyethoxy）ethoxy）methyl）oxirane. The structure of the copolymer was confirmed by ^1H NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.A novel poly（ethylene glycol） （PEG） analogue composed of aliphatic polyester backbone and pendant oligo（ethylene glycol） short chains is reported. The PEG analogue is a copolymer synthesized by ring-opening alternating copolymerization of succinic anhydride with 2-（（2-（2-metho xyethoxy）ethoxy）methyl）oxirane. The structure of the copolymer was confirmed by ^1H NMR spectrum. The effects of the monomer feed ratio on the copolymerization were studied and the polymerization mechanism was given. The PEG analogue disclosed is water-soluble and expected to have promising applications in biomedical fields as a substitute of PEG due to the existence of degradable ester bond in the backbone.

关 键 词：WATER-SOLUBLE PEG analogue 2-（（2-（2-Methoxyethoxy）ethoxy）methyl）oxirane Ring-opening alternating copolymerization Polyester 

分 类 号：TQ342.92[化学工程—化纤工业] O632.31[理学—高分子化学]