股骨头缺血性坏死100例患者的血脂观察与探讨  

Observation and Investigation of a series of blood-Iipid in 100 patients with ischemic necrosis of the femoral head.

作　　者：王洪彬[1] 贾艳岩[1] 康发军[1] 范志勇 王宝明[1] 陈峰[1] 

机构地区：[1]中国人民解放军第467医院,050081

出　　处：《河北医药》1998年第6期327-329,共3页Hebei Medical Journal

摘　　要：目的:进一步探讨股骨头缺血性坏死的致病因素及病理机制。方法:结合临床对100例股骨头缺血性坏死病人进行系列血脂及载脂蛋白化验分析,并与健康对照组对比,进行统计学处理,分析血脂对该病形成的影响。结果:股骨头缺血性坏死病人血脂含量增高,其中甘油三酯(TG)、脂蛋白(a)[Lp(a)]、载脂蛋白B(apoB)明显增高(P<0.01),高密度脂蛋白胆固醇(HDL-C)明显减低(P<0.01)。应用激素组TG显著高于非激素组(P>0.01),Lp(a)、apoB、HDL-TC两组无显著性差异(P>0.01)。结论:股骨头缺血性坏死与脂类代谢密切相关,并与遗传因素有关,Lp(a)血浆浓度的增高是股骨头缺血性坏死的危险因素,可导致终末小动脉的动脉粥样硬化及血栓形成。为及早发现或判断该病的发生趋势,达到有效防治目的,Lp(a)水平的检测具有重要临床意义。Objective: To investigate pathogenic factor and pathological mechanism of the is-chemic necrosis of the femoral head furthur. Metheds: A series of blood-lipid and apolipoprotein of 100 patients with ischcmic necrosis of the femoral head were determined, comparacd with contral and analyzed statistically to investigate blood-lipid' s role in forming the ischemic necrosis of the femoral head. Results:Blood-lipid level of the patients was higher than the control. TG, Lp(a) and apoB were no significant difference between two groups( P >0.05). Conclusions: The ischcmic necrosis of the femoral head is closely related to lipid metabolism and genetic factor. The increase of plasma Lp(a) concentration is a risk factor of this disease. The Lp(a) probably bring athcrosclcosis and therombosis to terminal artcriole. In order to finding and judging the evolutionary tendency of the ischcmic necrosis of the femoral head and reaching effectively the aim of prevention and cure, de-tection of the Lp(a)level is of important clinical sinificance.

关 键 词：股骨头坏死 缺血性坏死 脂蛋白 载脂蛋白 病理 

分 类 号：R681.802[医药卫生—骨科学]