Vaspin：一种新的具有胰岛素增敏作用的脂肪因子  

Vaspin ： a novel insulin-sensitizing adipocytokine

作　　者：瞿茹怡[1] 张安[1] 

机构地区：[1]上海市第一人民医院内科,200081

出　　处：《国际内分泌代谢杂志》2009年第6期405-407,共3页International Journal of Endocrinology and Metabolism

摘　　要：腹内脂肪来源的丝氨酸蛋白酶抑制剂（vaspin）是从OLETF（Otsuka Long-Evans Tokushima fatty）大鼠的腹内脂肪分离鉴定出来的一种脂肪因子。人类血清vaspin水平具有性别差异，并与肥胖、胰岛素抵抗指数相关。动物实验表明，vaspin可以改善糖耐量和胰岛素敏感性。因此，vaspin或其类似物有望成为治疗代谢综合征的一种新药。Vaspin, which is a member of serine protease inhibitor family, was isolated from visceral white adipose tissues（WATs） of OLETF rat, an animal model of abdominal obesity with type 2 diabetes. Human serum vaspin presented a sexual dimorphism arid was associated with parameters of obesity, insulin resistance, and glucose metabolism. And it can improve glucose tolerance and insulin sensitivity in vivo. So vaspin recombinant protein or its analogs may be the novel drug to treat metabolic syndrome.

关 键 词：VASPIN 脂肪因子 肥胖 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]