基质金属蛋白酶9及基质金属蛋白酶抑制因子1与急性心肌梗死后心室重构  

Relationship between Matrix Metalloproteinase-9/Tissue Inhibitor-1 of Metalloproteinases and Ventricular Remodeling after Acute Myocardial Infarction

作　　者：代西艳[1] 杨景宁[1] 

机构地区：[1]茂名市人民医院,广东茂名525000

出　　处：《医学综述》2009年第23期3529-3531,共3页Medical Recapitulate

摘　　要：急性心肌梗死后心室梗死区和非梗死区结构及形态的改变,导致心室重构,可引起心室泵血功能低下而最终发展为心力衰竭。基质金属蛋白酶9与基质金属蛋白酶抑制因子1处于动态平衡,对维持细胞外基质降解与合成起重要作用。Structure and morphological changes in infracted and non-infracted ventricular area after acute myocardial infarction lead to ventricular remodeling, thus can cause ventricular pump dysfunction and ul- heart failure. The dynamic balance of matrix metalloproteinase-9 and the tissue inhibitor-1 of metalloproteinases play an important role in maintaining the degradation and synthesis of extracellular matrix.

关 键 词：基质金属蛋白酶9 基质金属蛋白酶抑制因子1 心室重构 

分 类 号：R542.2[医药卫生—心血管疾病]