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作 者:钟淼[1,2] 郭颖 邓建云[1,2] 王文杰 程桂芳[1,2]
机构地区:[1]中国医学科学院中国协和医科大学药物研究所 [2]中国医药研究开发中心
出 处:《药学学报》1998年第11期812-815,共4页Acta Pharmaceutica Sinica
摘 要:目的旨在研究异丹叶大黄素和白藜芦醇对中性粒细胞功能的影响。从兔外周血分离中性粒细胞,检测用炎性四肽(fMLPP)诱导中性粒细胞趋化及β葡糖醛酸酶活性。结果显示:fMLPP诱导中性粒细胞趋化的最适浓度为5×10-10mol·L-1。在10-10~10-6mol·L-1的浓度范围内,fMLPP能剂量依赖性地促进中性粒细胞β葡糖醛酸酶释放。异丹叶大黄素与白藜芦醇在一定浓度范围内均能抑制fMLPP诱导的中性粒细胞的趋化。提示二者均能增强中性粒细胞的功能,可能是他们抗炎作用的机制之一。In effects of isorhapotigenin and resveratrol on chemotaxis and release of β glucuronidase from rabbit peripheral blood polymorphonuclear leukocytes stimulated with formylmethionyl leucyl phenyl phenylalanine(fMLPP) were studied. The optimal concentration of fMLPP for the induction of chemotaxis of polymorphonuclear leukocytes was approximately at 5×10 -10 mol·L -1 . fMLPP, at the concentration range of 10 -10 ~10 -6 mol·L -1 , dose dependently increased the release of β glucuronidase from polymorphonuclear leukocytes. Isorhapotigenin and resveratrol both inhibited the chemotaxis of polymorphonuclear leukocytes stimulated with fMLPP(5×10 -10 mol·L -1 ). Isorhapotigenin, at the concentration range of 10 -5 ~10 -4 mol·L -1 , dose dependently inhibited the release of β glucuronidase from polymorphonuclear leukocytes stimulated with fMLPP(10 -8 mol·L -1 ). Resveratrol, at the concentrations of 1×10 -5 and 3×10 -5 mol·L -1 , was shown to dose dependently inhibit β glucuronidase release from polymorphonuclear leukocytes stimulated with fMLPP(10 -8 mol·L -1 ).
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