新生儿不规则抗体检测的临床意义  

Clinical significance of irregular antibodies detection in newborn

作　　者：石祖亮[1] 魏中南[1] 涂同涛[2] 

机构地区：[1]湖北省妇幼保健院,武汉430070 [2]华中科技大学同济医学院附属同济医院输血科

出　　处：《临床血液学杂志（输血与检验）》2009年第6期638-639,642,共3页Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)

摘　　要：目的:检测新生儿红细胞血型不规则抗体,探讨不规则抗体与新生儿溶血病的关系。方法:对521例新生儿溶血病待确诊患儿通过微柱凝胶卡进行直接抗人球白试验、游离抗体测定、放散试验,不规则抗筛选阳性标本进一步进行不规则抗体鉴定,同时进行不规则抗筛选阳性患儿母亲血型鉴定及不规则抗体筛选、鉴定。结果:检测出抗-D4例,抗-E3例,抗-c1,抗-M1例。结论:应重视孕妇IgG类红细胞血型不规则抗体筛查;根据不规则抗体的特性,可为患儿选择无相应抗原的血液进行综合治疗和换血。Objective： To study the relation between the irregular antibodies and hemolytic disease of newborn （HDN） by detecting the irregular antibodies of newborn red blood cells. Method：The serum irregular antibodies of 521 newborns were detected with direct Coombs test, free antibody detection and elution test, and irregular anti bodies were identified with microcolumn gel coombs. Blood group and irregular antibodies were detected in the mothers whose children had positive irregular antibodies. Result：There were 4 cases of IgG anti D, 3 cases of IgG anti-E,1 case of IgG anti-c and 1 case of IgG anti M. Conclusion：Irregular antibody detection of pregnant woman has important clinical value in diagnosing non ABO HDN. It would be possible to select blood without correspond ing antigens according to the characteristics of irregular antibodies for combined therapy and exchange transfusion of the HDN children.

关 键 词：不规则抗体 新生儿溶血病 微柱凝胶卡 

分 类 号：R556[医药卫生—血液循环系统疾病]