手性包公藤甲素类似物的制备及其生物活性  

THE PREPARATION AND BIOACTIVITIES OF CHIRAL ANALOGS OF BAOGONGTENG A

作　　者：杨丽敏[1] 王惠宁[1] 

机构地区：[1]上海第二医科大学化学教研室

出　　处：《药学学报》1998年第11期832-835,共4页Acta Pharmaceutica Sinica

摘　　要：用化学拆分技术制备了８个手性包公藤甲素类似物，经兔眼缩瞳或扩瞳试验表明，其中（－）３α对甲苯磺酰氧基６β乙酰氧基莨菪烷有拟胆碱作用。Eight chiral analogs of baogongteng A were prepared from (±) 3α hydroxy 6β acetoxytropane by chemical resolution. In myotic or mydriatic tests in rabbits, (-) 3α paramethyl benzenesulfonyloxy 6β acetoxytropane showed cholinergic activities, while (+) 3α benzoyloxy 6β acetoxytropane and (+) 3α parachloro benzoyloxy 6β acetoxytropane showed anticholinergic activities.

关 键 词：包公藤甲素 类似物 制备 生物活性 

分 类 号：TQ464.4[化学工程—制药化工] R971.9[医药卫生—药品]