焦炉作业工人血浆热应激蛋白70kD抗体滴度及肿瘤坏死因子水平的研究  

STUDY ON THE LEVEL OF TUMOR NECROSIS FACTOR AND THE DILUTION OF ANTIBODY TO HEAT STRESS PROTEIN 70 IN WORKERS EXPOSED TO COKE OVEN EMISSION

作　　者：海涛[1] 陈胜[1] 王瑞波[1] 邬堂春[1] 丁焱焱[2] 吴芙蓉 万才珍[2] 曾丹[2] 张晓敏[2] 孙恩林[2] 

机构地区：[1]同济医科大学职业医学研究所,武汉430030 [2]武钢工业卫生与安全技术研究所

出　　处：《工业卫生与职业病》1998年第6期343-345,共3页Industrial Health and Occupational Diseases

基　　金：湖北省科委资助;武汉钢铁公司资助

摘　　要：为探讨焦炉逸散物及高温对作业工人血浆HSP70抗体滴度及肿瘤坏死因子（TNF）的影响，运用酶联免疫吸附鉴定法检测了85名焦炉工和73名非焦炉工血浆HSP70抗体滴度和TNF－α的含量。结果显示，焦炉工有51人出现1：10抗体阳性，21人出现1：20抗体阳性，分别占60％、28．2％；非焦炉工有23人出现1：10抗体阳性，11人出现1：20抗体阳性，分别占31．5％、15．1％，两组相比，差异有显著性（P＜0．05）。TNF的含量焦炉组明显高于对照组，差异有显著性（P＜0．05）。结果表明，焦炉逸散物和高温可导致机体受损、免疫功能发生紊乱。In order to explore the effects of coke oven emission (COE) and high temperature on the dilution of antibody against HSP70 and tumor necrosis factor (TNF ) in plasma of workers,the dilution of antibody and contents of TNF-αof 85 exposed workers and 73 control workers were determined with enzyme-linked immunosorbent assay. The results showed that 51 exposed workers had a dilution of 1: 10 and 24 ones of 1: 20 whose positive rates were 60%, 28. 2% respectively, while in the control group there were 23 with 1: 10 and 11 with 1: 20 whose positive rates were 31. 5%,1 5. 1 % respectively. There existed a significant increase of TNF-α and the dilution of antibody against HSP70 (P<0. 05) in exposed group. These results suggested that COE and high temperature could result a immune disorders and cell damage in exposed workers.

关 键 词：焦炉逸散物 热应激蛋白 抗体滴度 肿瘤坏死因子 

分 类 号：R135[医药卫生—劳动卫生] R992[医药卫生—公共卫生与预防医学]