戊型肝炎患者血清sIL-2R水平变化及临床意义探讨  

Study on the Change of SIL-2R Level and its Significance in Patients with HEV Infection

作　　者：李建忠[1] 李长缨[1] 张娴[1] 樊立人 侯青顺[1] 

机构地区：[1]山东省青岛市传染病医院,266033

出　　处：《预防医学文献信息》1998年第4期315-317,共3页Liferatue and Information On Preventine Medicine

摘　　要：为探讨戊型肝炎病人血清sIL-2R水平变化及其临床意义、分别对65的戊肝病人急性期及恢复期血清进行了sIL-2R、ALT及T-Ril水平动态测定.结果显示,戊肝极期及恢复期血清sIL-2R水平均显著高于恢复期、各组间sIL-2R水平存在显著性差异(P<0.01～0.05);sIL-2R水平与同期血清ALT及T-Bil呈显著的正相关,r值分别为0.56(P<0.01)和0.38(P<0.05);戊肝极期sIL-2R水平与戊肝病程中肝功能恢复所需的时间呈非常显著的正相关, r值为0.58(P<0.01),而其下降速度则与肝功能恢复所需时间是非常显著的负相关.r值为-0.67(P<0.01).提示,细胞免疫在戊型肝炎致病中起重要作用,sIL-2R水平及动态监测可较好地反映戊型肝炎的病情变化.To study the change of sIL-2R level in serum(slL-2R) of patients with HEV infection and its significance, the serums of 65 patients suffered from HE were detected during the acute and convalescent stages in order to determine the change of sIL-2R. ALT and total Bilirubin levels. The results showed that sIL-2R levels in both acute and convalescent stages were significantly increased as compared with that of the control group,and it was higher in the acute stage than in the convalescent stage. There was an obvious difference among different groups (P<0. 01~ 0.05). The sIL-2R level was positively related to those of ALT and T-Bilirubin in the same serum(γ=0. 56,P<0. 01 ;γ=0. 38.P<0. 05),and also to the phase for patients with HEV infection from acute state to recovery state(γ= 0. 58 ,P<0. 01) .which was negatively related to the falling speed of sIL-2R level(r= - 0. 67.P<0. 01 ). It seemed that cellular immunity played an important role in HEV development which could be estimated by dynamic measurement of sIL-2R level.

关 键 词：戊型肝炎 细胞免疫 白细胞介素2 受体 

分 类 号：R512.630.3[医药卫生—内科学]