雌激素受体-α基因多态性与湖南女性原发性膝骨性关节炎的关系  

Study on Relationship Between Polymorphisms of Estrogen α Receptor Gene and Primary Knee Osteoarthritis Among Women in Hunan

作　　者：田智[1] 郭小芳[1] 周锋[1] 黄春霞[1] 粟敏[1] 龙晓蕾[1] 刘立鹏[1] 

机构地区：[1]长沙医学院生物化学与分子生物学教研室,湖南长沙410219

出　　处：《实用预防医学》2009年第6期1724-1727,共4页Practical Preventive Medicine

基　　金：湖南省教育厅资助项目(项目编号:08C148)

摘　　要：目的探讨ER-α基因多态性与中国湖南女性原发性膝关节OA的关系。方法选取原发性膝OA女性患者38例、正常对照组40例。应用PCR-RFLP法对其进行ER-α基因PvuII和XbaI多态性检测。结果女性中,ER-α基因XbaI酶切基因型在OA组和对照组的分布差异有统计学意义,等位基因x和X的分布频率其差异亦有统计学意义。结论携带ER-α基因XbaI酶切基因型xx的女性对原发性膝OA易感。Objective To analyze the association between Pvull, Xbal polymorphism of the ER-α gene and primary knee osteoarthritis （OA） among women in Hunan Province. Methods Thirty- eight patients with primary knee OA and 40 / healthy controls were enrolled into this study. The genotype of ER-α gene was analyzed by polymerase chain reaction restriction fragment length polymorphism （PCR - RFLP）. Results The genotype distribution and the allele frequency of Xbal polymorphism of ER-α gene were statistically significant different between female primary knee OA patients and female control individuals. ConcLusion Females with the xx genotype of Xbal polymerphism of ER -α gene are susceptible to primary knee OA.

关 键 词：骨性关节炎 雌激素受体 基因多态性 聚合酶链反应-限制性片段长度多态性检测法 

分 类 号：R684.3[医药卫生—骨科学]