历节汤治疗湿热夹瘀型痛风临床研究  

Clinical Syudy on Curative Effects of Gout With Moist Heat And With Blood Stasis Syndrome Treated By Lijietang Decoction Combined With Colchic

作　　者：张高锋 刘敏 韩庆龙 邱英明 

机构地区：[1]宜昌市中医院,湖北宜昌443000 [2]厦门中医院,福建厦门361000

出　　处：《辽宁中医药大学学报》2009年第12期112-113,共2页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:探讨历节汤治疗痛风的临床疗效、安全性及不良反应,通过设立对照组,进行治疗前后自身比较以及组间比较,探索更为有效安全的治疗方法。方法:将70例入选的急性痛风性关节炎发作期患者随机分成治疗组35例,对照组35例。治疗组采用口服中药"历节汤"治疗;对照组采用口服西药秋水仙碱和双氯芬酸钠缓释胶囊治疗,观察两组治疗前后临床症状改善、UA、ESR、CRP的变化,并对上述结果进行统计学处理。结果:(1)观察指标的变化:与治疗前相比,治疗后在降低UA、ESR、CRP方面两组治疗前后均有非常显著差异(P<0.01)。(2)治疗组与对照组比较UA、HOMA-IR方面差异显著(P<0.05)。(3)在改善临床症状方面治疗组明显优于对照组(P<0.01),两者有非常显著差异。(4)不良反应:治疗组服用秋水仙碱后出现5例腹泻,4例呕吐,6例食欲不振,对照组未发现不良反应。Objective： This study objective is to approach the clinic therapeutic effect, security and adverse effect of the Lijietang to gout, to search for a more secure and more effective treating method of Chinese Traditional Medicine, by setting up control group and comparing interclass transversally of the pretherapy and posttherapy.Methods ： In this experiment, 70 cases of patients with the acute gouty arthritis were selected in the research and they were divided into two groups randomly. 35 patients were selected as the treatment group （treated with ＂Lijietang＂ ）, The patients in control group （35 cases） were treated with routine therapy in Western medicine, including Colchicine, Diclofenac Sodium Enteric-Coated Tablets and Allopurinol Tablets. The clinical symptoms, UA, ESR, CRPwere measured and compared before and after the treatment.Result ： The changs of guide line ： （ 1 ） Compared with pretherapy, the UA, ESR, CRP in the two groups in post-treatment are lower.The differences were highly significant （P〈0.01）; （ 2 ）The differences of UA, HOMA-IR between the treatment group and the control group were significant （P〈0.01）; （3）The melioration of the marks of clinical symptoms in the treatment group is higher than control group, the differences were highly significant （ P〈0.01 ）; （ 4 ）The adverse effects： In the two groups no abnormalities were found in the three routine examinations, hepatic function, renal function. In the acute gouty arthritis, the control group, there are 7 patients who had light diarrhea, 6 patients had Vomiting disease and 5 patients had poor appetite.In the gouty remission, 2 patients had skin rash in the control group. But no one was find in the treatment goup.Conclusions： The treatment group could reduce Serum uric acid, erythrocyte sedimentation rate（ESR） and C-reactive protein（CRP）, and improve patients＇ clinical symptoms. It＇s a effective method to treat gout with moist heat and blood stasis syndrome.

关 键 词：痛风 历节汤 临床研究 

分 类 号：R593[医药卫生—内科学]