快速复极化电流对心肌细胞电生理特征的影响  

Effect of rapid repolarization current on electrophysiological characteristic of myocardial cells

作　　者：李云飞[1] 鲁刚[1] 李纪树[1] 王彪[2] 

机构地区：[1]沈阳工业大学辽阳校区基础部,辽宁辽阳122026 [2]辽宁科技大学理学院,辽宁鞍山114051

出　　处：《辽宁科技大学学报》2009年第5期474-477,共4页Journal of University of Science and Technology Liaoning

摘　　要：针对增大快速复极化电流对心肌细胞动作电位、钾离子浓度及电生理特征的影响问题,沿用毕勒-路特心肌细胞数理模型,以一阶龙格-库达法进行计算,研究心肌细胞外加刺激使动作电位、钾离子浓度呈现周期性,结果更具有实际意义。研究结果表明,增大复极化电流使动作电位短期内出现震荡,钾离子电流密度初期减小,心肌细胞兴奋性、传导性、自律性降低,进而诱发心律失常。In view of the influence of rapidly enlarging repolarization current for action potential, K ion and electrophysiological characteristic, by adopting Beeler and Reuter myocardial cells mathematical model, and calculating in the first-order Runge-Kutta method, it was studied that myocardial cells in addition to stimu- lation made action potential, and K ion presented the periodicity, whose results possess more practical significance. The results indicate that rapidly enlarging repolarization current makes action potential shake in a short time, reduces K ion electric current density in initial time, causes myocardial cells excitability, conductivity and automatic rhythmicity reduction, and then induce arrhythmia.

关 键 词：心肌细胞 动作电位 复极化电流 

分 类 号：R318.04[医药卫生—生物医学工程] R541.7[医药卫生—基础医学]