药物涂层支架防治冠脉血管内再狭窄的研究进展  

Drug eluting stents prevent restenosis following stent implantation

作　　者：赵玉兰[1] 陈敏[1] 

机构地区：[1]郑州大学第二附属医院心血管内科,河南省郑州市450014

出　　处：《中国组织工程研究与临床康复》2009年第43期8532-8535,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:通过对目前研究和应用较为广泛的药物涂层支架进行讨论,进而探讨药物涂层支架对防治冠脉血管内再狭窄的作用。方法:应用计算机检索PubMed(1993/2009)和中国期刊全文数据库(CNKI:1993/2009),按纳入和排除标准,对文献进行筛选和质量评价。从目前最常用的雷帕霉素涂层支架和紫杉醇涂层支架防治冠脉血管内再狭窄的临床应用,讨论药物涂层支架在防治冠脉血管内再狭窄中的应用进展与存在的问题。结果:药物涂层支架可以很好地减少支架后血管内再狭窄的发生,但在临床应用中仍然存在着贴壁不良、支架断裂等其他问题。结论:药物涂层支架防治冠脉血管内再狭窄的有效性和安全性均较良好。但是药物涂层支架存在的一系列问题有待于进一步研究解决。OBJECTIVE： To discuss the research and clinical application of drug eluting stents, in addition, to explore the effects of drug eluting stents on preventing and curing coronary restenosis. METHODS： The databases of Medline and Chinese CNKI were retrieved using computer from 1993 and 2009, and the literature was selected according to inclusion and exclusion criteria. The rapamycin eluting stent and paclitaxel eluting stent were widely used in preventing and curing in stent restenosis, the problems existed in this process were discussed. RESULTS： Drug eluting stents could prevent in stent restenosis following stent implantation, however, the problems such as poor adherence or stent fracture still occurred in clinic. CONCLUSION： Drug eluting stents exhibit efficiency and safety in preventing restenosis, but there still existed problems need to further explore.

关 键 词：药物涂层支架 支架置入 血管内再狭窄 

分 类 号：R318[医药卫生—生物医学工程]