光和热对盐酸氯丙嗪注射液稳定性的影响  

Influence of light and heat on the stability of Chlorpromazine hydrochloride injection

作　　者：侯满州[1] 李成容[1] 詹先成[1] 王英利[1] 韩雪[1] 向超群[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2009年第6期623-624,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的研究盐酸氯丙嗪注射液在光和热作用下的稳定性。方法采用恒温加速试验和高温光照试验进行考察。结果高温条件下,盐酸氯丙嗪注射液的降解符合一级动力学规律;光照条件下,符合零级动力学规律。结论光照下提高温度可增大降解速率,降解速率的大小与波长有关。OBJECTIVE To study the effects of light and heat on the stability of Chlorpromazine hydrochloride injection. METH- ODS The isothermal experiments and accelerated tests upon exposure to light at high temperature were employed. RESULTS The drug degradation rate obeyed first - order kinetics in the isothermal experiment, and the exposure experiments to light complied with the zero -order dynamics. CONCLUSION The higher temperature the greater rate of degradation, the degradation rate is relevant to wavelength of light.

关 键 词：光 热 盐酸氯丙嗪注射液 动力学 

分 类 号：R913[医药卫生—药学]