消风散抗炎活性的动物实验研究  

Experimental study on anti-inflammatory activity of Xiaofengsan

作　　者：温炬[1] 陈宝田[1] 兰海梅[2] 李慧[1] 林中方[3] 阮一民[3] 马静[3] 冯洁莹[3] 

机构地区：[1]南方医科大学南方医院中医科,广州510515 [2]南方医科大学南方医院皮肤科,广州510515 [3]广东省第二人民医院皮肤科,广州510317

出　　处：《广东医学》2009年第12期1772-1774,共3页Guangdong Medical Journal

基　　金：广东省科技计划资助项目(编号:2008B030301162);广东省中医药局基金资助项目(编号:2008210)

摘　　要：目的探讨消风散(XFS)对组胺致大鼠足肿胀的影响。方法50只大鼠随机分为低、中和高剂量消风散模型组、阳性对照模型组、阴性对照模型组各10只。相应灌服低、中和高剂量消风散、西替利嗪(阳性对照)和生理盐水(阴性对照)等药物7 d。通过给大鼠左前爪足跖皮下注射0.1 mL新鲜配制的组胺(1.0 mg/mL)构建鼠爪水肿模型。分别于造模后0.5、1、1.5、2、2.5 h测量足趾体积。2.5 h取足趾组织,利用光镜电镜观察病理改变。结果消风散各组在0.5、1、1.5、2 h时能显著降低大鼠足爪肿胀率,光镜和电镜观察显示消风散组、阳性对照组和阴性对照组之间有差异。结论消风散具有一定的拮抗组胺作用。Objective To study the effects of Xiaofengsan（XFS） on toe swelling of rats induced by histamine. Methods A total of 50 rats were randomly divided into low dose of XFS model group, medium dose of XFS model group, high dose of XFS model group, positive control model group, and negative control model group. Each group had 1 0 rats. The five groups were administrated respectively with low, medium, and high dose of XFS, Cetirizine, and normal saline for 7 days. Each model group of rats was subcutaneously injected with histamine （ 1.0 mg/ml） in left forepaws. At 0. 5, 1, 1.5, 2. 0, 2. 5 h after injection, the volumes of forepaws were measured, and the tissues on forepaws were sampled and prepared for routine pathological examination and electron microscopy. Results Swelling rates of forepaws in XFS model group significantly decreased at 0.5, 1, 1. 5, 2.0 h, and routine pathological examination and electron microscopy revealed differences among the grouos. Conclusion XFS can antagonize histamine to some extent.

关 键 词：消风散 组胺 实验研究 

分 类 号：R289.5[医药卫生—方剂学] R914.5[医药卫生—中药学]