18α-、18β-甘草酸及其不同配比物对大小鼠的抗炎作用  

Investigation of anti-inflammatory effect among 18α-、18β-glycyrrhizic acids and their different proportions in rats and mice

作　　者：茹仁萍[1] 赵灏[1] 陈晓瑾[1] 唐红英[1] 

机构地区：[1]杭州市第六人民医院,浙江杭州310014

出　　处：《中国医院药学杂志》2009年第23期1995-1998,共4页Chinese Journal of Hospital Pharmacy

基　　金：杭州市卫生局项目(编号:2005060)

摘　　要：目的:观察并比较18α-、18β-甘草酸(GL)及其不同配比物的抗炎作用。方法:制备小鼠和大鼠急性炎症模型,观察18α-、18β-GL及其不同配比物对二甲苯致小鼠耳肿胀、角叉菜胶致大鼠足跖肿胀和四氯化碳致大鼠急性肝损害的影响,并对其抗炎作用进行比较。结果:小鼠耳肿胀实验显示α-与β-GL比例为3∶7时对耳肿胀有抑制作用,在抑制角叉菜诱发的大鼠足肿胀实验中,氢化可的松组与α-、β-GL比例为5∶5,4∶6和3∶7能明显抑制足肿胀。各给药组均能提高四氯化碳致肝脏损害后的血清白细胞介素-6(IL-6)水平,并且β-GL和4∶6,3∶7配比组提高明显。结论:α-、β-GL抗炎效果存在着差异,并且不同比例的两者配比物所表现出来的抗炎能力随着比例的改变而改变。α-GL和β-GL比例为4∶6与3∶7体现出较强的抗炎效果,有开发成新一代甘草酸制剂的潜力。OBJECTIVE To investigate the anti-inflammatory effect of 18α-, 18β-glycyrrhizie acids（GL） and their different proportions, and select the optimum formulation. METHODS Anti-inflammatory effect of GL were carried through acute inflammatory models： ear swelling induced by dimethylbenzene in mice, paw edema induced by carrageen glue in rats and hepatic inflammation induced by carbon tetrachloride in rots, the anti-inflammatory effects were evaluated by swelling degree and interleukin-6 （IL-6） expression in serum. RESULTS The 3：7 proportion of 18α- and 18β - GL showed anti-inflammatory action on ear swelling in miee; when the proportion were 5：5,4：6 and 3：7, the paw edema could be significantly inhibited compared to the control; GL all increased the content of IL- 6 after hepatic injury, especially 18β-GL and proportions of 4：6 and 3：7. CONCLUSION The anti-inflammatory effects of 18α- and 18β-GL were different, and the anti-inflammatory activity of their proportions changed with the ratio. The proportion of 4：6 and 3：7 were more potent, and had the potential to be developed into new products.

关 键 词：18Α-甘草酸 18Β-甘草酸 抗炎作用 大鼠 小鼠 

分 类 号：R969[医药卫生—药理学]