多索茶碱在大鼠体内的时辰药动学  

The chronopharmacokinetics of doxofylline in rats

作　　者：王淑君[1] 熊建华[1] 周曙华[1] 

机构地区：[1]温州市第三人民医院药剂科,浙江温州325000

出　　处：《中国医院药学杂志》2009年第23期2009-2011,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察多索茶碱不同时间给药的药动学差异。方法:16只大鼠在8∶00,20∶00两个不同时间点,按80.0mg.kg-1多索茶碱口服给药,于0.08,0.25,0.5,1.0,1.5,2.0,3.0,5.0,7.0h后取血,分别测定其血浆药物浓度,并按非房室模型计算药动学参数。结果:大鼠于8∶00和20∶00给药,其药动学的主要参数t1/2、AUC(0-7)、MRT(0-7)、Vz/F、CL/F、tmax、Cmax等差异无显著性(P>0.05)。结论:多索茶碱在大鼠体内的药动学参数没有明显的昼夜节律性变化。OBJECTIVE To observe the change of pharmacokinetics of doxofylline in rats by single oral administration at different time. METHODS Sixteen rats were given a single dose of doxofylline 80 mg·kg^-1 at 8 ： 00 and 20： 00 respectively. The blood was taken out at 0. 08,0. 25,0. 5,1.0, 1.5,2. 0,3. 0,5. 0,7. 0 h. The concentrations of doxofylline in plasma was determined and the pharmacokinetic parameters of non-compartment model were calculated. RESULTS The main pharmacokinetic parameters of doxofylline t 1/2 ,AUC（0-7）、MRT（0-7）、Vz/F、CL/F、Tmax、Cmax were not significantly different in rats by oral administration at 8：00 and 20：00（P〉0. 05）. CONCLUSION The pharmacokinetics of doxofylline has no obvious change in circadian rhythms in rats.

关 键 词：多索茶碱 药动学 时间节律 高效液相色谱法 

分 类 号：R96[医药卫生—药理学]