多囊卵巢综合征患者瘦素水平与胰岛素抵抗的相关性研究  

Study on the relationship between serum leptin level and insulin resistance in polycystic ovary syndrome

作　　者：程瑞迎[1] 董进[2] 

机构地区：[1]山西省人民医院,030012 [2]山西医科大学第一医院

出　　处：《实用医技杂志》2009年第12期956-957,共2页Journal of Practical Medical Techniques

基　　金：山西省自然科学基金资助(991088)

摘　　要：目的了解多囊卵巢综合征(PCOS)患者瘦素水平与胰岛素抵抗(IR)的相关性。方法30例PCOS患者为研究组,30名健康孕龄妇女作为对照组。测定血清瘦素、空腹血糖(FBG)、空腹胰岛素(FIns)等水平,并计算胰岛素抵抗指数(HOMA-IR)。结果PCOS患者血清中的瘦素及Fins水平均高于对照组,差异有统计学意义(P<0.01);健康体质量和肥胖的PCOS组HOMA-IR显著升高(P<0.05,P<0.01)。PCOS患者中瘦素与体质量指数(BMI)、FIns、HOMA-IR呈正相关(r=0.586,P<0.01;r=0.483,P<0.01;r=0.539,P<0.01)。结论PCOS患者存在瘦素水平增高和胰岛素抵抗,二者具有相关性,且血清瘦素水平与PCOS的胰岛素抵抗可能有关。Objective To investigate the relationship between serum lepin level an insulin resistance in polycystic ovary syndrome （PCOS）. Methods Thirty PCOS patients and thirty health women were divided into the experimental group and control group, respectively. The concentration of the serum lepin, fasting blood sugar （FBG）, fasting insulin （Fins） in all the subjects mentioned above were measured. The insulin sensitivity was evaluated by Homeostatic Model Assessment （HOMA-IR）. Results The level of serum lepin, Fins and HOMA-IR in PCOS group were much higher than those in the control group （P〈0.01）. There was a positive correlationship between the level of the serum lepin and the body mass index （BMI）, Fins, HOMA-IR （r=0.586, P〈0.01; r=0.483, P〈0.01; r=0.539, P〈0.01） in PCOS group. Conclusion The level of serum lepin in PCOS group were higher, and correlated with the insulin resistance.

关 键 词：多囊卵巢综合征 瘦素 胰岛素抵抗 

分 类 号：R711.75[医药卫生—妇产科学]