再次TURP患者前列腺组织微血管密度、血管内皮生长因子和雄激素受体的表达及意义  

Microvessel density and expression of VEGF and AR in the prostates of men who received re-operation after TURP for benign prostatic hyperplasia

作　　者：管同郁[1] 孙庆增[2] 戚景光[1] 曹敬毅[1] 吴刚[1] 杨宁[1] 承征宇[1] 梁杰[1] 王乾[1] 

机构地区：[1]江苏大学附属徐州医院,徐州市第三人民医院泌尿外科,221005 [2]江苏大学临床医学院

出　　处：《中华泌尿外科杂志》2009年第12期845-847,共3页Chinese Journal of Urology

摘　　要：目的 探讨再次TURP患者前列腺组织微血管密度（MVD）、血管内皮生长因子（VEGF）和雄激素受体（AR）表达的临床意义。方法再次TURP手术患者50例。选取2次手术标本（再次TURP组），50例首次手术患者标本作为对照组。采用免疫组织化学SIP法检测标本组织中CD34、VEGF、AR的表达，通过血管内皮特异的CD34染色计数MVD值。统计学比较3组标本MVD、VEGF、AR的表达水平。结果再次TURP组1、2次手术标本和对照组标本MVD值分别为35．83±20．92、32．16±16．65和20．56±6．99，VEGF阳性表达率分别为82．0％（41例）、84．0％（42例）和60．0％（30例），AR阳性表达率分别为84．0％（42例）、88．0％（44例）和64．0％（32例），再次TURP组首次标本MVD值、AR及VEGF阳性表达率均高于对照组，差异有统计学意义（P〈0．05）；再次TURP组2次手术标本间各指标差异无统计学意义（P〉0．05）。结论BPH患者前列腺组织中高MVD值及AR、VEGF高表达是导致TURP术后复发及再次手术的重要原因之一。Objective To discuss microvessel density（MVD） and expression of vascular endothelial growth factor（VEGF）, androgen receptor（AR）in the prostates of men who received re-operation after TURP. Methods Fifty cases were performed re-TURP（re-TURP group） and the remaining 50 cases served as controls. 150 specimens were collected. Sections were stained for CD34 and VEGF.AR by immunohisto-chemistry（S-P）. Statistical analysis of the results was performed using t-test or Pearson Chi-Square test. Results The expression of VEGF. AR and MVD were significantly higher in the re-TURP group compared to controls（P〈0. 05） ,but in re-TURP group, difference in VEGF and AR expression as well as MVD were not found to be significantly different between the first and the second TURP（P〉0.05）. Conclusion Over expression of VEGF and AN as well as high MVD in prostatic tissue might play an important role in the pathological process of BPH after TURP.

关 键 词：经尿道前列腺电切术 再手术 微血管密度 血管内皮生长因子 雄激素受体 

分 类 号：R686[医药卫生—骨科学]