IL-1Ra对阿霉素肾病大鼠血清IL-6、IL-10、IL-13、IL-1的影响  

EFFECTS OF IL-1 RECEPTOR ANTAGONIST ON SERUM IL-6,IL-10,IL-13,AND IL-1 LEVELS IN ADRIAMYCIN NEPHROSIS IN RATS

作　　者：林娜[1] 刘运广[1] 覃志坚[2] 李强[1] 

机构地区：[1]广西右江民族医学院附属医院儿科,百色533000 [2]广西右江民族医学院附属医院科学实验中心,百色533000

出　　处：《广西医科大学学报》2009年第5期660-663,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.30460137);广西自然科学基金资助项目(No.桂科自0229061);广西科学研究与技术开发计划项目(No.桂科基01410251);广西卫生厅科研基金资助项目(No.9955)

摘　　要：目的:探讨IL-1Ra对阿霉素肾病大鼠血清IL-6、IL-10、IL-13、IL-1的影响。方法:将大鼠随机分为正常对照组(A组,n=10)、阿霉素肾病组(B组,n=10)、阿霉素肾病IL-1Ra治疗组(C组,n=10)、阿霉素肾病生理盐水治疗组(D组,n=10),2周后检测尿24hUP、血清IL-6、IL-10、IL-13、IL-1、Al、T-ch、BUN、Scr。结果:B、C、D组血清IL-6、IL-10、IL-13水平明显高于A组(P<0.01),IL-1Ra治疗后,24hUP、T-ch较B、D组及C组IL-1Ra治疗前明显降低(P<0.01),Al、IL-6、IL-10、IL-13水平均较B、D组及C组IL-1Ra治疗前增高(P<0.05),IL-1血清水平较B组、D组、C组IL-1Ra治疗前明显降低(均P<0.01),接近A组水平(P>0.05)。结论:IL-1Ra对阿霉素肾病大鼠有明显治疗作用的同时能提高抗炎细胞因子IL-6、IL-10、IL-13的血清水平。Objective：To study the effects of IL-1 receptor antagonist on serum IL-6,IL-10,IL-13,and IL-1 levels in rats with adriamycin（ADR） nephrosis. Methods： The rats were randomly dividied into the control group （group A, n = 10）, the ADR nephrosis group （group B, n = 10）, the IL-1Ra on ADR nephrosis group （group C, n = 10）, the sodium chloride on ADR nephrosis group （group D, n = 10）,and the changes of the urine protein （UP）, serum IL-6, IL-10, IL-13, albumin （ A1）, total cholesterol （ TC）, urea nitrogen （UN）, and creatinine（Cr） levels were detected after two weeks. Results：The levels of serum IL-6, IL-10, and IL-13 were higher in groups B,C and D than those in group A（ P〈0. 01）. After IL-1Ra treatment, the levels of the 24h UP and TC were significantly decreased in groups B and D（ P d0.01） ,and the levels of albumin, IL-6,IL-10 and IL-13 were increased（ P 〈0. 05）. After treated with IL-1Ra,serum levels of IL-1 were significantly lower in ADR group than in groups B, D and before treated with IL-1Ra groups （ P〈 0.01）, compared with control group, there was not significant difference （ P 〉0.05）. Conclusion： The results suggest a significant therapeutic effect of IL-1Ra on the ADR nephrosis,and elevates the levels of serum anti-inflammatory cytokine.

关 键 词：白细胞介素-1受体拮抗剂 肾病 白细胞介素-6 白细胞介素-10 白细胞介素-13 

分 类 号：R692[医药卫生—泌尿科学]