创伤性休克患者黏附分子的变化及意义  

ALTERATION AND SIGNIFICANCE OF ADHESION MOLECULE IN TRAUMATIC SHOCK PATIENTS

作　　者：陈荣剑[1] 林洪武[1] 彭咏梅[1] 黄宗海[2] 

机构地区：[1]中国人民解放军第184医院外科,鹰潭335000 [2]南方医科大学附属珠江医院普外科,广州510282

出　　处：《广西医科大学学报》2009年第4期524-526,共3页Journal of Guangxi Medical University

基　　金：南京军区医学科学技术研究"十一五"计划课题(编号06MA81)

摘　　要：目的:探讨创伤性休克患者血清与脏器黏附分子P-选择素的变化及意义。方法:采用酶联免疫法(ELISA)测定血清中P-选择素变化,同时采用免疫组织化学方法(SABC法)检测患者(骨骼肌、脾脏、小肠)P-选择素的表达。结果:正常对照组血清中P-选择素即有表达,创伤休克患者血清及脏器中P-选择素含量明显升高。结论:创伤可导致P-选择素大量表达,这与创伤时存在明显的微循环紊乱和内皮功能障碍有关。Objective：To investigate the alteration and significance of adhesion molecule（P selection） in serum and organs during traumatic shock. Methods：The serum P-selectin level was assayed by enzyme linked immunosorbent assay and P-selectin expression in organs including somatic muscles, spleen and small intesine was determined by means of streptavidin-biotin immunocytochemical staining technique. Result：The Pselectin was expressed in normal control. The level of P-selectin was significantly increased in traumatic shock patients. Conclusion：The level of P-selectin is expressed in great quantity during tranma. It is related to the marked microcirculatory disturbance and endothelial dysfunction.

关 键 词：创伤 P-选择素 黏附分子 

分 类 号：R641[医药卫生—外科学]