湖南省HIV感染者合并HCV或TB感染分析  

HIV-infected people combined with HCV or TB coinfection in Hunan Province

作　　者：尹伟[1] 郑煜煌[1] 何艳[1] 王敏 朱章萍 符政远[4] 申红连 刘凤秀[6] 王为德 郑力文[8] 

机构地区：[1]中南大学湘雅二医院,湖南长沙410011 [2]长沙市第一医院传染病分院,湖南长沙410011 [3]衡阳市第三人民医院,湖南衡阳421005 [4]怀化市第一人民医院,湖南怀化418000 [5]岳阳市第一人民医院,湖南岳阳414000 [6]娄底市中心医院,湖南娄底420000 [7]湘潭市第五人民医院,湖南湘潭411100 [8]中南大学湘雅医学院临床八年制,湖南长沙410013

出　　处：《中国感染控制杂志》2009年第6期384-388,共5页Chinese Journal of Infection Control

摘　　要：目的对湖南省人免疫缺陷病毒(HIV)感染者合并丙型肝炎病毒(HCV)、结核(TB)感染的情况进行流行病学调查和分析,评估合并感染的患病率及相关影响因素。方法对该省各医院2006—2008年收治的门诊和住院HIV感染病例,以统一的流行病学调查表进行登记;对各地区的现患HIV感染病例进行HCV抗体和TB抗体检测;用SPSS软件对不同因素下HIV合并HCV或TB感染的情况进行统计学分析。结果共调查978例病例,HIV合并HCV的感染率为33.95%(332例)。其中通过静脉吸毒感染HIV的患者合并HCV感染率为81.06%(321/396);30～44岁年龄组HIV合并HCV的感染率为42.60%(262/615);无业人员HIV合并HCV感染率为61.89%(302/488),上述3组HIV合并HCV感染率均明显高于其相关的其他各组(分别P<0.0125,P<0.0125,P<0.0045)。HIV合并TB的感染率为26.99%(264/978),其中静脉吸毒感染HIV者并发TB率35.86%明显高于性传播感染者的19.65%(P<0.0071);CD4+T淋巴细胞计数≤200个/μL组HIV患者合并TB率为41.59%,明显高于其他组(均P<0.(0125)。结论首次报告湖南省HIV合并HCV、TB的感染现状及其相关影响因素。静脉吸毒是HIV合并HCV感染的主要传播途径,30～44岁年龄组和无业人群合并感染率较高。HIV合并TB的感染率在CD4+T淋巴细胞计数≤200个/μL的HIV感染者中患病率较高。Objective To explore HIV-infected people coinfected with HCV or TB in Hunan Province, and assess the incidence and related factors. Methods HIV infected inpatients and outpatients in local hospitals in Hunan Province between 2006 and 2008 were surveyed by questionnaires, existing cases of HIV infected persons were performed detection of HCV and TB antibody; HIV and HCV or TB coinfection were analysed statistically with SPSS software. Results A total of 978 cases were investigated, HIV and HCV coinfection rate was 33.95% （332 cases）. The coinfecion rate of HIV and HCV in intravenous drug user, persons at the age of 30 - 44 and the jobless persons was 81.06% （321/396）, 42. 60%（262/615）and 61.89% （302/488） respectively; coinfection rate of HIV and HCV in above three groups were all higher than the other related groups （P〈0. 0125, 〈0. 0125, 〈0. 0045）.Infection rate of HIV combined TB was 26. 99% （264/978）, coinfection rate in intravenous drug users（35.86%） was obviously higher that （19. 65%） in patients through sex（P〈0. 0071 ）. Coinfection rate of HIV and TB in pa tients with CD4＋ T cell count ≤ 200/ μL was 41.59%, which was higher than that in other groups （both P〈7 0. 0125）. Conclusion It is the initial report on state and related factors of HIV combined with HCV or TB coinfection. Intravenous drug use is the most principal way for HIV-infected patients infect with HCV. Patients for HIV/ HCV coinfection are concentrated on the age of 30 - 44 years old and the jobless. The incidence of tuberculosis in HIV patients with CD4 ＋ T cell count ≤200 /μL is higher than other HIV patients.

关 键 词：艾滋病 人免疫缺陷病毒 丙型肝炎病毒 结核 合并感染 危险因素 

分 类 号：R512.91[医药卫生—内科学]