68例维吾尔族IgA肾病患者MBL基因多态性与临床病理相关性分析  

Relation of Mannose Binding Lectin Gene Polymorphism to Clinico- pathological Features in IgA Nephropathy Patients with Xinjiang Uygur Nationality

作　　者：朱开春[1] 刘熔[1] 阿丽娅·克里木[1] 代建霞[1] 刘伟莉[1] 陆晨[1] 

机构地区：[1]新疆维吾尔自治区人民医院肾病科,乌鲁木齐市830001

出　　处：《医学分子生物学杂志》2009年第6期514-517,共4页Journal of Medical Molecular Biology

基　　金：资助项目：新疆维吾尔自治区自然科学基金（No.200521108）

摘　　要：目的探讨甘露糖结合凝集素（mannose—binding lectin，MBL）基因第54位密码子多态性与维吾尔族IgA肾病患者临床和病理的关系。方法应用PCR—RFLP方法对68例维吾尔族IgAN患者进行MBL多态性检测，并与患者临床和病理特点进行相关性分析。结果①维吾尔族IgAN中表现为蛋白尿的患者突变型等位基因GAC的发生频率显著高于表现为单纯血尿的患者（P〈0．05）；②维吾尔族IgAN中表现为复合性免疫沉积的患者等位基因GAC的发生频率显著高于表现为单纯免疫沉积的患者（P〈0．05）。结论MBL突变型等位基因GAC与维吾尔族IgAN蛋白尿发生和免疫复合沉积相关。Objective To investigate the relationship between mannose-binding lectin （MBL） gene polymorphism and clinicopathological features in IgA nephropathy （IgAN） patients with Xin- jiang Uygur nationality. Methods 68 patients with biopsy proven IgAN were identified from renal disease database. MBL codon 54 gene polymorphism was detected by PCR-RFLP. MBL genotype and allele frequency were compared between IgAN patients with different clinical manifestations or different patterns of glomerular immune deposits. Results Distribution of MBL codon 54 gene poly- morphism showed significant difference between Uygur IgAN patients with proteinuria and simple he- maturia. The genotype frequency of GAC heterozygote in Uygur IgAN patients with clinical proteinu- ria of multiple immune deposits was notably higher in those with clinical simple hematuria （ X2 = 5. 934, P 〈 0. 05） . Conclusion The GAC heterozygote of MBL gene condon 54 wase associated with clinical proteinuria and different patterns of glomerular immune deposits in Uygur IgAN patients.

关 键 词：IGA肾病 甘露糖结合凝集素 基因多态性 免疫沉积 

分 类 号：R692.6[医药卫生—泌尿科学]