左西孟旦影响心衰患者B型利钠肽水平的Meta分析  

Effect of levosimendan on B-type natriuretic peptide levels in patients with advanced heart failure:a meta-analysis

作　　者：徐忠东[1] 何伟雄[2] 赵一凡[1] 夏淑轩[1] 何波[1] 杨涛[1] 曹德雄[1] 彭书崚[1] 李珏[1] 曹铭辉[1] 

机构地区：[1]中山大学附属第二医院麻醉科,广东广州510120 [2]中山大学附属肿瘤医院麻醉科,广东广州510060

出　　处：《南方医科大学学报》2009年第10期2027-2029,共3页Journal of Southern Medical University

基　　金：广东省科技计划项目(2007B030704005;2007B031500002)

摘　　要：目的Meta分析左西孟旦对失代偿心衰患者B型利钠肽(BNP)水平的影响,并评价左西孟旦在左心衰治疗中的疗效。方法采用Meta分析法对收集到的相关文献进行严格的定量分析。结果左西孟旦静脉用药后24h时BNP平均降低337.66pg/ml,其95%CI为(-296.30,-379.02);48h时平均降低259.92pg/ml,其95%CI为(-195.76,-324.08);第1周平均降低123.09pg/ml,其95%CI为(-53.32,-195.86)。各时点心功能与用药前相比约分别增加了29%、22%、10%。结论左西孟旦能改善失代偿心力衰竭患者心功能,显著降低血浆BNP水平。Objective To conduct a meta-analysis of the effect of levosimendan on B-type natriuretic peptide （BNP） levels and evaluate the therapeutic effect of levosimendan on advanced heart failure. Methods A meta-analysis was performed on the selected data to analyze the effect of levosimendan on BNP levels. Results Levosimendan decreased BNP by a mean of 337.66 [95%CI （-296.30, -379.02）] pg/ml 24 h after the administration, and by 259.92 [95%0 （-195.76, -324.08）] pg/ml at 48 h, and by 123.09 [95%CI （-53.32 ,-195.86）] pg/ml at 1 week. Levosimendan resulted in improvements of the cardiac function by about 29%, 22%, and 10% at 24 h, 48 h and 1 week after the administration. Conclusion Levosimendan produces favorable effects on the cardiac functions and BNP levels.

关 键 词：左西孟旦 心力衰竭 B型利钠肽 META分析 

分 类 号：R541.6[医药卫生—心血管疾病]