灵杆菌多糖抗肿瘤及抗免疫抑制作用的研究  

Effects of lipopolysaccharides of Becterium prodigiosum on tumor growth and immunosuppression in mice

作　　者：余传林[1] 朱正光[1] 雷林生[1] 常花蕾[1] 高慧灵[1] 陈娜娜[1] 阳先国[1] 

机构地区：[1]南方医科大学药学院药物研究所,广东广州510515

出　　处：《南方医科大学学报》2009年第10期2133-2134,2137,共3页Journal of Southern Medical University

摘　　要：目的研究灵杆菌多糖对肿瘤生长的抑制作用和对抗免疫抑制的作用。方法建立小鼠荷S-180实体瘤模型,以及环磷酰胺诱导的免疫抑制小鼠模型,观察腹腔注射灵杆菌多糖对肿瘤生长、免疫器官指数、外周白细胞数的影响。结果荷S-180实体瘤小鼠连续8d腹腔注射灵杆菌多糖40U/kg对肿瘤生长有显著的抑制作用(P<0.01),并显著地提高荷瘤小鼠的脾脏指数,但对胸腺指数无明显影响。灵杆菌多糖腹腔注射连续7d,对环磷酰胺所致的免疫低下小鼠的外周血白细胞数和脾指数的降低有显著的对抗作用,对正常小鼠的各指标没有显著性的影响。结论灵杆菌多糖对对荷瘤小鼠和免疫低下小鼠有抑制肿瘤生长,增强免疫功能的作用。Objective To observe the effects oflipopolysaccharides of Bacterium prodigiosum （BP-LPS） in inhibiting tumor growth and improving immunosuppression in mice. Methods In mice bearing S180 tumor and a mouse model of immunosuppression induced by cyclophosphamide （CTX）, the tumor growth, indexes of the immune organs and peripheral white blood cell count were measured after intraperitoneal injection of BP-LPS. Results Injections of BP-LPS （40 U/kg） for 8 consecutive days resulted in a significant inhibition of the tumor growth in mice bearing S180 tumor （P〈0.01）, with a dose-dependent increase of the spleen indexes but no obvious changes in the thymus indexes, lntraperitoneal injections of BP-LPS for 7 days inhibited the reduction of peripheral white blood cells and spleen indexes in immunosuppressive mice, but did not produce any significant changes in normal mice. Conclusion BP-LPS can inhibit the tumor growth in tumor-bearing mice and enhance the immune functions of immunosuppressive mice.

关 键 词：灵杆菌 脂多糖 肿瘤 免疫 

分 类 号：R285.5[医药卫生—中药学]