氟芬合剂、咪唑安定和异丙酚治疗全麻苏醒期躁动的疗效观察  

Clinic curative efficacy on emergence agitation during recovery period of general anesthesia with compound of Droperidol and Fentanly,Midazuolam or Propofol

作　　者：曾金[1] 贾月姣[1] 务军[1] 陈蕙[1] 陈丽红[1] 黄蓓[1] 燕舒文[1] 李志芳[1] 

机构地区：[1]广西医科大学第五附属医院麻醉科,广西柳州545006

出　　处：《中国医药导报》2009年第35期59-60,62,共3页China Medical Herald

摘　　要：目的:观察氟哌啶-芬太尼合剂(氟芬合剂)、咪唑安定和异丙酚治疗291例全麻苏醒期躁动的疗效以及不良反应。方法:气管插管全麻导管拔除后发生躁动的291例患者随机分为对照组M组、P组,观察组FD组,每组97例。M组采用静脉注射咪唑安定0.06～0.10mg/kg,P组静脉注射异丙酚1.5～2.0mg/kg,FD组静脉注射氟哌利多-芬太尼合剂(氟哌利多0.05～0.10mg/kg,芬太尼1.0～2.0μg/kg)。观察三种方法治疗躁动的疗效、呼吸抑制(SpO2<90%)的程度以及治疗后再次清醒时间。结果:M组、P组和FD组控制躁动的有效率分别为61.86%、63.92%和88.66%,FD组明显高于其他两组(P<0.05)。三种方法引起呼吸抑制的发生率无显著性差异(P>0.05)。FD组和P组再次清醒的时间均明显早于M组(P<0.05),FD组和P组间无显著性差异(P>0.05)。结论:氟芬合剂治疗全麻苏醒期发生的躁动疗效高、苏醒快,副作用小,值得临床应用。Objective： To observe the curative efficacy and side-effect of 291 patients being pulled out tracheal canula during the recovery period emerging agitation with compound of Droperidol and Fentanly, Midazolam or Propofol. Methods： 291 patients with emergence agitation during the recovery period,after had been pulled out the tracheal canula, were randomly divided into three groups, including two control groups （group M and group P） and an observational group （group FD）, 97 patients in each group. Patients in group M were injected with Midazolam （0.06-0.10 mg/kg）, Propofol （1.5-2.0 mg/kg） in group P and with compound of Droperidol （0.05-0.10 mg/kg ）and Fentanyl （1.0-2.0 μg/kg） in group FD. Then we observed the clinic curative efficacy on the emergence agitation, the incidence of respiratory inhibition （SPO2〈90%） and the sober time after three different treatments. Results： The rate of curative efficacy in group M, group P and FD was 61.86%, 63.92% and 88.63% respectively, the efficient rate in group FD was significantly higher than that of the other groups （P〈0.05）. The sober time after treatment in group FD and group P was earlier than that of group M （P〈0.05） and there was no significant difference between group FD and group P （P〉0.05）. There was no difference in respiratory inhibition among three groups after treatment （P〉0.05）. Conclusion： The compound of Droperidol and Fentanly is the most effective method to treat the emergence agitation, which deserves clinic application on account of its high efficacy, quick regaining consciousness and little side-effect.

关 键 词：全麻苏醒期 躁动 氟哌利多-芬太尼合剂 治疗 

分 类 号：R614.2[医药卫生—麻醉学]