甲亢性骨质疏松症不同治疗的临床研究  

Clinical Comprehend of Combined Therapy to Osteoporosis Caused by hyperthyroidism

作　　者：连韩[1] 胡耀梅[1] 

机构地区：[1]湖北省荆门市第一人民医院内分泌科,448000

出　　处：《中国临床实用医学》2009年第12期31-33,共3页China Clinical Practical Medicine

基　　金：基金项目：湖北省荆门市科技计划项目（项目编号：2007YSD06）

摘　　要：目的探讨放射性碘与其他药物治疗甲状腺机能亢进对骨质代谢的不同影响。方法对60例甲亢性骨质疏松患者随机分为A组B组C组，C组进行I131治疗，A组给予甲巯咪唑片治疗，B组给予甲巯咪唑片同时联用钙吸收剂治疗，治疗不同阶段观察症状和骨密度（BMD）改善情况。结果C组治疗后3个月有效、6个月后显效达到十分满意的疗效（95％以上），自觉症状（骨痛）改善明显（总疗效93％），BMD与用药前比较差异有显著统计学意义（P〈0．01）。A组B组用药后3个月无效、6个月后有效患者的自觉症状（骨痛）改善（总疗效73％），B组有效，与用药前BMD比较无统计学差异（P〉0．05），BMD改变的总疗效不满意（64％）。结论甲亢性骨质疏松症治疗是一个系统而长期的过程，甲亢治愈后骨质疏松多可恢复正常，但将放射性碘（I131）治疗与甲亢的骨质疏松有机结合在一起，会在较短的时间达到满意的疗效。Objective To investigate I131 therapeutic efficacy of osteoporosis caused by hyperthyroidism. Methods 60 cases of osteoporosis caused by hyperthyroidism were randonmly divided into following groups：Agroup, B group andC group. Cgroup were treated by I131. A group and B group were treated by medicine therapy. The improvement of symptom and bone mineral density（BMD） were observed. Results There were no difference for BMD treating with medicine compared ahead and after 3 months （ P 〉 0. 05 ）. There were signifi- cant difference for BMD treating with I131 compared ahead and 6 months（ P 〈 0. 01 ）. The subjective symptom （osteodynia） after treating with medicine for 3 months was improved obviously （overall curative effect was 83% ） ,The overall curative effect of BMD improments were unpreparedness（64% ）. The compared satisfying overall curative effect （ about 80% ） were appeard after 6 months. The well contentcurative effect （ above 97 % ） was showed up after 6 months. Conclusion I131 therapy is the first method to osteoporosis caused by hyperthyroidism Treating osteoporosis is a genealogy and long term process, the therapeutic effect of is fairly I131 satisfied.

关 键 词：甲亢 骨质疏松症 骨密度 

分 类 号：R580[医药卫生—内分泌]