焊工血脂质的过氧化改变  

A Study on Changes of Blood Lipid Peroxidation in Welders

作　　者：赵肃[1,2,3,4] 王任群[1,2,3,4] 曹昆[1,2,3,4] 高成城 曲奎娟[1,2,3,4] 曹瑞 

机构地区：[1]沈阳医学院 [2]沈阳市大东区防疫站 [3]沈阳矿山机器厂 [4]沈阳中捷友谊厂医院

出　　处：《中国工业医学杂志》1998年第6期321-323,共3页Chinese Journal of Industrial Medicine

摘　　要：为探讨焊接烟尘与焊工血脂质过氧化两者间的相互关系，对某电焊车间７１名焊工血中Ｍｎ、Ｃｒ、Ｎｉ含量和脂质过氧化水平进行了检测，同时分析了该车间空气中烟尘和该三元素的浓度。结果表明，焊工血中Ｍｎ为５．９０μｇ／Ｌ，明显高于对照组；抗氧化酶活力（ＳＯＤ、ＣＡＴ、ＧＳＨ－Ｐｘ）、丙二醛含量（ＭＤＡ）与对照组比较差异有显著意义，ＳＯＤ、ＭＤＡ尤为明显；焊接烟尘浓度与焊工血中ＭＤＡ含量存在明显相关（ｒ＝０．４６８，Ｐ＜０．０１）。提示电焊工人机体脂质过氧化水平增高是长期吸入焊接烟尘所致。Blood levels of manganese,chromium,nickel and lipid peroxidation were deter mined in 71 welders in an electric welding workshop and its air concentrations of welding fume and the three elements mentioned above were detected in order to explore the relationship between exposure to welding fume and their blood lipid peroxidation level.Results showed that blood level of manganese averaged 5 90μg/L in welders,significantly higher than that in controls,and there was significant difference in activities of anti oxidase(SOD,CAT and GSH Px)and level of malonic dialdehyde(MDA),especially in SOD and MDA,between the welders and controls.Air concentrations of welding fume correlated with blood level of MDA in welders,with an r of 0 468,P<0 01.It suggested that the increased level of lipid peroxidation in the welders was caused by long term inhalation of welding fume.

关 键 词：脂质过氧化 抗氧化酶 焊接烟尘 

分 类 号：R131[医药卫生—劳动卫生] R115[医药卫生—公共卫生与预防医学]