对苯二甲酸粉尘接触量与肺通气功能的关系  

Studies on Relationship between Dose of Exposure to Terephthalic Acid Dust and Pulmonary Ventilation Function

作　　者：吴仲华 曹晋柱 朱道明 杜冰 颜馨泉 龚楠 徐锡坤[1,2] 何冬宁 汪建平[1,2] 王心如 

机构地区：[1]杨子石化公司医院职防所 [2]南京医科大学公共卫生学院

出　　处：《中国工业医学杂志》1998年第6期337-340,共4页Chinese Journal of Industrial Medicine

基　　金：国家卫生部资助;江苏省科委自然科学基金

摘　　要：目的研究对苯二甲酸（ＴＰＡ）对职业人群肺通气功能的影响。方法对１１６名ＴＰＡ作业工人和同一地区年龄、性别、身高、体重、吸烟情况类似的５４名正常对照工人进行肺通气功能的测定分析。结果接触组ＶＣ、ＦＶＣ、ＦＥＶ１．０、ＰＥＦＲ、Ｖ·７５和Ｖ·５０显著低于对照组（Ｐ＜０．０５或Ｐ＜０．０１），且肺通气功能变化与接触ＴＰＡ浓度有关。肺通气功能异常者以阻塞型为主；吸烟因素与接尘因素可能产生协同作用。结论作业人群肺通气功能的变化与接触对苯二甲酸有密切关系。Objective To study the effects of terephthalic acid (TPA) on pulmonary ventilation function in the exposed workers.Methods Pulmonary ventilation function was examined and analyzed in 116 workers exposed to TPA and 54 normal controls matched on age,sex,body height and weight,and smoking status.Results Vital capacity(VC),forced vital capacity(FVC),forced expiratory volume in one second(FEV 1 0 ),peak expiratory flow rate(PEFR),and expiratory flow rate at 75% and 50% of expired vital capacity ( V · 75 and V · 50 ),respectively,were significantly lower in the exposed workers than in the controls(P<0 05 or P<0 01).Changes in their pulmonary ventilation function correlated to the TPA concentrations they exposed.Most of their abnormality of ventilation function was obstructive in manner,on which smoking and dust exposure could act synergetically.Conclusion Changes in pulmonary ventilation function was closely correlated to TPA they exposed.

关 键 词：对苯二甲酸 肺通气功能 粉尘 接尘量 

分 类 号：R135.2[医药卫生—劳动卫生]