胰岛素抵抗在非胰岛素依赖型糖尿病患者继发冠心病中的作用  

A Study of Insulin Resistance for CHD Followed as a Complication of NIDDM

作　　者：马骏[1] 王正伦[1] 王建华[1] 

机构地区：[1]天津医科大学公共卫生学院

出　　处：《中国慢性病预防与控制》1998年第6期277-279,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：为研究冠心病（ＣＨＤ）的发病危险因素，对１０２例非胰岛素依赖型糖尿病（ＮＩＤＤＭ）继发ＣＨＤ病例进行多个配比病例对照研究。通过条件Ｌｏｇｉｓｔｉｃ回归分析，发现胰岛素抵抗及高血糖症是ＮＩＤＤＭ继发ＣＨＤ的危险因素，ＯＲ分别为２．５６（９５％ＣＩ１．２７～５．１６）、４．３２（９５％ＣＩ２．５６～７．２８），高胰岛素血症增加ＮＩＤＤＭ继发ＣＨＤ的危险性，ＯＲ为１．６０（１．０３～２．４７）。Coronary heart disease(CHD) is currently the leading cause of death among the diabetes population.In order to investigate the risk factors of clinical NIDDM with CHD,a multiple group pair matched case control study with 102 cases was conducted.The data were analyzed with conditional Logistic regression method.The results showed that insulin resistance and hyperglycemia were risk factors causing secondary CHD.The higher of fasting blood glucose and the more serious insulin resistance,the higher risk of secondary CHD became.The values of OR were 2.56(95% CI 1.27￣5.16) and 4.32(95% CI 2.56￣7.28) respectively.Hyperinsulinemia contributed to the risk of secondary CHD, OR was 1.60(1.03￣2.47).

关 键 词：糖尿病 冠心病 胰岛素抵抗 发病学 

分 类 号：R587.1[医药卫生—内分泌] R541.4[医药卫生—内科学]