1，5-脱水葡萄糖醇用于筛查糖尿病的研究  

1,5-Anhydroglucitol as a Screeing Test Effects for Diabetes Mellitus

作　　者：陈家坚[1] 叶余辉[1] 温卓莲[1] 

机构地区：[1]北海市人民医院检验科,广西北海536000

出　　处：《现代检验医学杂志》2009年第6期68-70,共3页Journal of Modern Laboratory Medicine

基　　金：广西壮族自治区卫生厅计划课题（2007007）.

摘　　要：目的评价血清1，5-脱水葡萄糖醇（1，5-AG）在筛查糖尿病（DM）中的应用价值。方法应用受试者特征（ROC）曲线对50例2型糖尿病（T2DM）、100例糖耐量减低（IGT）及30例正常对照组的1，5-AG，FBG及HbAlc水平进行比较与分析。结果①糖尿病组1，5-AG水平显著低于正常对照组和糖耐量减低组（P〈0．01），糖耐量减低组1，5-AG低于正常对照组（P〈0．05）；③1，5-AG，F13（3和HbAlc的ROC曲线下面积分别为0．948，0．921，0．817，对DM具有较高的诊断价值；⑧1，5-AG，FBG和HbAlc分别以14mg／L，6．2mmol／L和6．4％作为诊断参考值，其敏感度分别为90．0％，88．0％，82．0％；特异度分别为93．3％，90．O％，76．7％。结论1，5-AG可作为糖尿病诊断、筛查和血糖控制监测的指标。Objective To assess the validity of using serum 1,5-anhydroglucitol （1,5-AG） for the screeing of diabetes mellitus （DM）. Methods By using the receiver operating characteristic （ROC） curve,this essay evaluates the diagnostic effects of 1,5-AG,FBG and HbAlc to 50 case T2DM, 100 case IGT and 30 control subject. Results （1）serum 1,5-AG was obviously lower in the diabetes than that in IGT and controls（P〈0.01）. Compared with control,IGT patients had lower 1,5-AG（P〈0.05）. （2）The under-curve area of 1,5-AG,FBG and HbAlc were 0. 948,0. 921 and 0. 817,respectively. All show a satisfied diagnostic effect. （3）It approved that the best cut-off point of 1,5-AG,FBG and HbAlc would be 14 mg/L, 6.2 mmol/L and 6.4% respectively,it was figured out that the sensitivity was respectively 90.0 % ,88. 0 % and 82.0% the specificity of 93.3%,90. 0% and 76.7%. Conclusion 1,5-AG can be used as a useful indicator in the diagnosis and screen of diabetes mellitus as well as in the monitoring of glycem in control.

关 键 词：ROC曲线 1 5-脱水葡萄糖醇 糖尿病 糖耐量减低 

分 类 号：R587.1[医药卫生—内分泌] R446.112[医药卫生—内科学]