应用限制性片段长度多态性分析技术研究乙醇脱氢酶2的基因多态型  

Study on the polymorphism of alcohol dehydrogenase gene 2 (ADH2) by RFLP technique.

作　　者：屈卫东[1,2,3] 吴德生[1,2,3] 吴玮 山县然太郎 王云波 张雪 浅香昭雄 

机构地区：[1]华西医科大学公共卫生学院环境卫生教研室 [2]乌鲁木齐石油化工厂医院妇产科 [3]日本山梨医科大学

出　　处：《中国优生与遗传杂志》1998年第6期6-7,共2页Chinese Journal of Birth Health & Heredity

摘　　要：分子遗传学技术的发展使得我们对与遗传有关疾病的认识达到了新的境界。通过产前对个体所携有的基因多态型的研究可以对某些疾病进行早期预测，从而达到预防、优生优育的目的。酒精脱氢酶２基因就是一个鲜明的例子，个体带有的基因型不同其表现型也不同，它与胎儿酒精综合征、胎儿酒精效应及酒精相关疾病存在着一定联系。为此本文采用限制性片段长度多态性分析技术研究酒精脱氢酶２的基因，根据基因的变化。With development of molecular biology, we acknowledge genetic related diseases to reach a nwe status. by studying of individual carried polymorphism in prenatal, some disease can be predicted in early time. And then the destemination of both preventation and birth health were gotten. A apperancely instance is alcohol dehydrogenase. If individual carried difference genotype, its phenotype is also difference. They have some relationshp with syndrome, fetal alcohol, fetal alcohol effect, and alcohol related diseases. Therefore, utilizing restriction fragment length polymorphism (RFLP) technique can resarch genotype of alcohol delydregenase 2 (ADH2), according to changing of genotype, sensitive population were be screened. It provided basis for preventing fetal alcohol syndrome.

关 键 词：限制性片段长度多态性 乙醇脱氢酶基因2 基因多态型 

分 类 号：R596[医药卫生—内科学]