调平康片联合开搏通治疗原发性高血压临床研究  

Effects of Tiaopingkang Tablet Combined with Capoten for Essential Hypertension

作　　者：吴辉[1] 欧明[1] 丁有钦[1] 黄衍寿[1] 冼绍祥[1] 

机构地区：[1]广州中医药大学第一附属医院心内科

出　　处：《广州中医药大学学报》1998年第4期241-245,共5页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：为评价中药复方调平康片联合小剂量开搏通治疗原发性高血压的综合疗效，采用随机、双盲、对照方案将６１例合格高血压（ＥＨ）患者随机分为两组，分别予以调平康片加开搏通（中西药组）、安慰剂加开搏通（西药组）治疗。结果：２８ｄ后，其临床疗效为：西药组２９例，总有效率为６２．０７％，其中症状总有效率为５８．６２％，降压总有效率为７０．４１％；中西药组３２例，总有效率为７８．１３％，其中症状总有效率为８４．３８％，降压总有效率为７８．１３％，两组差异有显著性。此外，与西药组相比，中西药组更有效地改善了高血压病患者心脏舒张功能，降低了２４ｈ动态血压负荷。测定了血浆过氧化脂质（ＬＰＯ）、内皮素（ＥＴ）、内皮衍生舒张因子（ＮＯ）等物质的水平，其结果显示：高血压病患者血浆ＬＰＯ、ＥＴ水平较正常人高（Ｐ＜０．０５），ＮＯ水平减低（Ｐ＜０．０１）；中西药组治疗１个月后，能逆转上述异常，与西药组相比，差异也有显著性。结论：调平康片联合小剂量开搏通治疗高血压病比单用开搏通疗效要满意（Ｐ＜０．０５）。其疗效的取得，可能是通过抑制脂质过氧化，减轻ＬＰＯ对内皮细胞的损伤，恢复血管内皮细胞（ＶＥＣ）正常调控血压机能而实现的。A blinded randomized controlled trial was used to study the effect of Tiaopingkang Tablet combined with a small dosage of capoten for essential hypertension(EH).Sixty_one cases of EH were randomly allocated to two groups:Group I(32) was treated with Tiaopingkang Tablet and a small dosage of capoten,Group Ⅱ(29) received placebo and the same dosage of capoten.The results showed that after 28 days of treatment the total effective rates were 78.13% and 62.07% ,the symptomatic improvement rates were 84.38% and 58.62%,and the total effective rates in decreasing blood pressure were 78.13% and 70.41% in Group I and Group Ⅱ respectively. The differences were significant. The left ventricular function was improved and 24h blood pressure load reduced after treatment in Group Ⅰ as compared with Group Ⅱ(P< 0.05 ).The concentrations of serum lipid peroxide (LPO) and endothelin (ET) were higher(P<0.05) and the concentration of nitric oxide was much lower in cases of EH than those in normal person(P< 0.01 ).After one month of treatment the above indexes in Group Ⅰ improved while showed no changes in Group Ⅱ. It is concluded that Tiaopingkang Tablet combined with a small dosage of capoten is more effective than capoten alone for EH,and its mechanism is probably related to the inhibition of the damage of LPO to vascular endothelial cell(VEC) and the restoration of regulative effect of VEC for blood pressure.

关 键 词：高血压 中西医结合治疗 调平康 开搏通 

分 类 号：R544.105[医药卫生—心血管疾病]