超声波辐射法合成对叔丁基杯[8]芳烃酯类衍生物  

Synthesis of tert-Butyl Calix[8]Arene Ester Derivative Under Ultrasonic Radiation

作　　者：安琳[1] 陈海红[1] 秦真程[1] 丁杰[1] 

机构地区：[1]徐州医学院药学院,江苏徐州221004

出　　处：《化学研究》2009年第4期17-19,共3页Chemical Research

摘　　要：在超声辐射条件下,以对叔丁基杯[8]芳烃为原料,采用氯乙酸乙酯为烃基化试剂,KI为离子交换剂,在K2CO3/丙酮体系中进行衍生化反应可高效制备对叔丁基杯[8]芳烃乙酸乙酯基衍生物;讨论了超声功率、反应时间、原料摩尔配比及催化剂等因素对收率的影响.实验结果表明:使用200 W的超声功率,氯乙酸乙酯过量50%,反应时间为25 min时,精制后杯芳烃酯类衍生物收率达到82.2%.Under ultrasonic wave radiation,ester group fully substituted tert-butyl calix[8]arene derivative could be efficiently synthesized by using tert-butyl calix[8]arene as the raw material,ethyl α-chloroacetate as alkyl agent and KI as ionic exchanger in the system of K2CO3/acetone.The factors affecting the yields,such as ultrasonic radiation weight,reaction time,material molar ratio were discussed.The optimal conditions are： ultrasonic radiation weight 200 W,ethyl α-chloroacetate excess of 50%,radiation time 25 min. The method is easy to operate and control and has a high yield of up to 82.2%.

关 键 词：超声波辐射 对叔丁基杯[8]芳烃 氯乙酸乙酯 酯类衍生物 合成 

分 类 号：O644.3[理学—物理化学] O621.3[理学—化学]