诺卜二烯的合成及应用研究进展  

Research Progress on Synthesis and Application of Nopadiene

作　　者：隋管华[1,2,3] 赵振东[1,2,3] 毕良武[1,2,3] 李冬梅[1,2,3] 王婧[1,2,3] 

机构地区：[1]中国林业科学研究院林产化学工业研究所 [2]生物质化学利用国家工程实验室 [3]国家林业局林产化学工程重点开放性实验室,江苏南京210042

出　　处：《生物质化学工程》2009年第6期55-59,共5页Biomass Chemical Engineering

基　　金：科技基础性工作专项资助(2007FY230200);国家外专局智力引进项目(20080322011);"十一五"国家科技支撑计划资助(2007BAD82B01)

摘　　要：综述了诺卜二烯的合成方法及其在精细化工和有机合成中的应用。利用诺卜醇直接脱水反应、诺蒎酮的格氏反应、诺卜基醚或诺卜基磺酸酯的消去反应、硫代苯甲酸诺卜酯的光催化消去反应及桃金娘烯醛的Wittig反应等几种方法能够合成得到诺卜二烯。含共轭双键的诺卜二烯可直接用作精细化工配方成分,更多的是经过Diels-Alder反应用于合成香料、手性配体等物质,或者与含亲电基团的化合物反应合成一系列衍生物,或者作为单体合成聚合物产品。The synthesis and application of nopadiene in fine chemicals as well as in organic synthesis were reviewed. Nopadiene could be synthesized by the direct dehydration of nopol, the elimination of nopyl ethers or nopyl tosylate, the photo-degradation of nopyl thiobenzoic acid o-esters, and the reaction of nopinone with Grignard reagent, etc. Nopadiene with two conjugated double bonds can be applied as a fine chemical composition. However, the more nopadiene is applied to synthesize perfume, chiral ligand compounds through Diels-Alder reactions, or to synthesize some other related compounds through reactions with electrophilic groups, or to be polymerized as a monomer.

关 键 词：诺卜二烯 合成 应用 Diels—Alder反应 

分 类 号：TQ231.2[化学工程—有机化工]