抗精神病药物对精神分裂症患者体质量的影响及干预  

Study of Management of Body Mass Gain with Antipsychiatrics

作　　者：张平[1] 夏正飞 叶美荣 费春华[1] 李颖[1] 陈蕴辉 袁丹红[1] 

机构地区：[1]上海市奉贤区精神卫生中心,上海201418

出　　处：《药物流行病学杂志》2009年第6期396-398,共3页Chinese Journal of Pharmacoepidemiology

基　　金：上海市奉贤区科技发展基金(编号:07-1304)

摘　　要：目的:比较氯氮平与利培酮对精神分裂症患者体质量的影响并观察非药物干预效果。方法:氯氮平组和利培酮组治疗精神分裂症患者各30例,观察8周后将体质量增加15%以上者随机分为干预组和对照组共4组,再进行为期12周的饮食控制和增加运动干预。结果:氯氮平引起体质量增加的检出率为86.7%;利培酮66.7%,两组间差异无统计学意义(P>0.05);治疗8周后两组体质量均显著增加(P<0.01),氯氮平组体质量增加值明显高于利培酮组(P<0.05)。干预12周后两组体质量均明显下降(P<0.05),利培酮组体质量接近基线水平(P>0.05)。结论:利培酮和氯氮平治疗精神分裂症患者均可引起体质量增加,但前者影响较小,且饮食控制和增加运动干预有效。Objective： To compare the effect of clozapine and risperidone on the body mass and observing the effect of non - medicine intervention in it. Method： 30 schizophrenic patients were treated respectively with clozapine and risperidone. The patients with gaining weight over 15% after 8 weeks were randomly grouped into 4 groups, and then received dieting and exercising for 12 weeks. Result： The rate of weight gain over 15% was respectively 86.7% and 66.7% with no significant difference （ P 〉 0.05 ）. The weight of the patients in both clozapine group and risperidone group increased significantly（ P 〈 0.01 ） after 8 weeks with more weight increasing in the risperidone group than in the clozapine group （P 〈 0.05 ）. The body weight decreased significantly in both clozapine group and risperidone group after receiving dieting and exercising for 12 weeks（ P 〈 0.05 ） with the body weight close to the baseline level in the risperidone group（ P 〉 0.05 ）. Conclusion ： Both rispefidone and clozapine could result in the weight gain, but the effect of risperidone on it is weaker than that of clozapine. And dieting and exercising intervention are effective to the weight gain.

关 键 词：精神分裂症 氯氮平 利培酮 体质量 饮食控制 运动 

分 类 号：R971.41[医药卫生—药品]