布地奈德对内镜鼻窦术后术腔黏膜转归观察  

Clinical Obervation of Effect of Budesonide on Epithelization in Surgical Cavities Following Endoscopic Sinuous Surgery

作　　者：李俊[1,2] 白广平[2] 

机构地区：[1]复旦大学附属中山医院耳鼻咽喉科,上海200032 [2]复旦大学附属中山医院青浦分院耳鼻咽喉科

出　　处：《药物流行病学杂志》2009年第6期404-405,413,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨术腔应用布地奈德对内镜鼻窦手术(ESS)疗效的影响。方法:122例接受ESS的鼻窦炎患者随机分为治疗组(61例)和对照组(61例),两组接受相同的手术治疗和术后术腔清理。治疗组术腔加吸入用布地奈德混悬液行鼻内雾化,定时行内镜检查,观察术腔黏膜转归情况。结果:治疗组术后15d术腔清洁情况优于对照组,差异有显著统计学意义(P<0.01);治疗组术后3个月上皮化情况优于对照组,差异有统计学意义(P<0.05)。结论:内镜鼻窦手术术后应用布地奈德能明显促进术腔黏膜良性转归及上皮化,提高手术疗效,值得临床推广。Objective： To explore the therapeutic effect of the use of budesonide for externally-used budesonide in the surgical cavities following endoscopic sinuous surgery（ESS）. Method： 122 cases with chronic sinusitis were randomly divided into two groups treated by the routine procedures after endoscopic sinuous surgery but the treatment group with 61 cases were treated by the addition of budesonide suspension for inhalation in the surgical cavities. The process of the epithelization in the surgical cavities by endoscopy was investigated. Result： The process of cleaning in 15 days in the surgical cavities was better in the budesonide-using group than in the controlled group. A significant difference was found （ P 〈 0.01 ） . The process of the three-month epithelization was better in the surgical cavities in the budesonide-using group than in the controlled group and there was a significant difference between them （ P 〈 0.05 ）. Conclusion ： The use of budesonide in the surgical cavities following endoscopic sinuous surgery could promote the process of the epithelization in the surgical cavities with a significantly shortened duration of this process and promote the therapeutic effect of surgery.

关 键 词：内镜鼻窦术 布地奈德 术腔上皮化 

分 类 号：R977.11[医药卫生—药品]