正交优选β-环糊精包合复方藿香片中挥发油的实验研究  

Study on the Preparation of β-cyclodextrin Inclusion Compounds of Essential Oil in Fufang Huoxiang Pian by Orthogonal Test

作　　者：陈赟[1] 

机构地区：[1]华南理工大学化学与化工学院,广东广州510640

出　　处：《时珍国医国药》2009年第12期3018-3019,共2页Lishizhen Medicine and Materia Medica Research

基　　金：传热强化与过程节能教育部重点实验室开放基金项目(No.KF0701)

摘　　要：目的研究β-环糊精包合复方藿香片中混合挥发油的制备工艺。方法采用正交实验设计,以挥发油包合率和包合物得率的综合评分为评价指标,优选β-环糊精包合复方藿香片中挥发油的最佳工艺条件。结果最佳挥发油包合工艺条件为:β-环糊精∶挥发油(g∶ml)为10∶1,包合温度50℃,包合时间40 min,β-环糊精:水为1∶5。结论该工艺挥发油包合率及包合物收率较高,包合效果良好。Objective To study optimum inclusion process conditions for essential oil from Pogostemon cablin （Blanco） Benth, Pefilla frutescens（ L. ） Britt. and Aconistatatinow ii Schott （A. gramineus Soland） in Fufang Huoxiang Pian. Methods The utili- zation ratio of volatile and the inclusion rate were determined to evaluate process conditions, and the condition was optimized with orthogonal design by the liquid - phase method in aqueous solution. Results The optimum preparation conditions for inclusion were established as： oil： β -CD was 1：10, and ratio of amount of water to β -CD was 5. The inclusion temperature and time were at 50℃ and for 40 min. Conclusion The yield is high in the optimum process condition and purpose of inclusion was achieved.

关 键 词：复方藿香片 正交实验 包合 挥发油 

分 类 号：R284.2[医药卫生—中药学]