利用冷冻干燥原位构筑仿生型纳米羟基磷灰石、壳聚糖多孔支架材料  

Biomimetic Synthesis of Porous Composite Scaffold Composed of Nano-Hydroxyapatite and Chitosan by Freeze-Drying Technology

作　　者：陈景帝[1] 王迎军[2] 陈晓峰[2] 尹诗衡[2] 

机构地区：[1]福州大学,福建福州350002 [2]华南理工大学,广东广州510640

出　　处：《稀有金属材料与工程》2009年第A03期271-273,共3页Rare Metal Materials and Engineering

基　　金：国家"973"计划(2005CB623902);国家自然科学基金项目(50472054;50572029)

摘　　要：在目前仿生制备骨缺损修复材料研究的基础上,利用冷冻干燥技术结合原位复合方法在成分仿生的基础上进行结构仿生制备骨缺损修复材料。充分利用壳聚糖的溶解、沉析和羟基磷灰石形成特性,在室温下实现了纳米羟基磷灰石在多孔支架中的纳米分散。研究结果表明,利用冷冻干燥原位构筑的多孔支架材料拥有很好的相互贯穿多孔连通结构,孔径分布为100～136μm,孔隙率达到96.1%。此外,原位形成的纳米羟基磷灰石(95nm)对于多孔支架还起到了纳米增强作用,支架表现出良好的力学性能,可以根据不同缺损形状实现随意赋行。体外生物活性测试表明,该支架材料具有很好的生物活性,是一种优越的潜在骨缺损修复支架材料。Based on the present research about repairing materials for bone defect, a novel porous composite scaffold was prepared through freeze-drying technology combining with in situ method. The characteristics of the chitosan and hydroxyapatite （HAP） were made full use. The porous scaffold had inter-connected pores with 100-136 μm in diameter and the porosity was 96.1%. The nano HAP achieved nano dispersion in the scaffold by the biomimetic method at room temperature and improved the mechanical property of the scaffold. Vitro test shows that it is a bioactive scaffold.

关 键 词：冷冻干燥 原位复合 多孔支架 

分 类 号：R318.08[医药卫生—生物医学工程]