宁夏回族原发性高血压人群HLA-DQB1基因多态性分析  

Analysis on polymorphisms of HLA-DQB1 gene in Ningxia Hui polulation with essential hypertension

作　　者：徐金瑞[1] 杨易[1] 张东涛[1] 高力扬[1] 王玉炯[1] 

机构地区：[1]宁夏大学西部特色生物资源保护与利用教育部重点实验室,宁夏银川750021

出　　处：《吉林大学学报（医学版）》2009年第6期1103-1106,共4页Journal of Jilin University：Medicine Edition

基　　金：教育部科学技术研究重点项目资助课题(205172);宁夏大学自然科学基金资助课题(ZR0603)

摘　　要：目的:分析HLA-DQB1基因多态性在宁夏回族人群原发性高血压(EH)患者中的分布,阐明宁夏回族人群原发性高血压的易感性。方法:采用序列特异性引物聚合酶链式反应(SSP-PCR)的方法对宁夏回族66例健康个体(对照组)及84例EH患者(病例组)的HLA-DQB1位点进行基因分型,应用遗传学统计方法分析宁夏回族原发性高血压人群DQB1基因多态性。结果:病例组等位基因DQB1*0301、*0401、*0601、*0604/5/6/7、*0302频率显著高于对照组(P<0.01或P<0.05);病例组等位基因DQB1*0501、*0602、*0603/8、*0606、*0402、*0604/5/6/8频率显著低于对照组(P<0.01或P<0.05)。结论:DQB1*0301、*0401、*0601、*0604/5/6/7、*0302与宁夏回族人群原发性高血压的易感性有关,而DQB1*0501、*0602、*0603/8、*0606、*0402、*0604/5/6/8有可能是宁夏回族人群原发性高血压的保护因子。Objective To investigate the susceptibility to essential hypertension（EH） in Ningxia Hui population based on the distribution of the polymorphisms of HLA-DQB1 in EH population. Methods PCR-SSP method was conducted to examine the genotypes of HLA-DQB1 in 66 healthy individuals and 84 EH patients,and the genotypic and allelic frequencies were statistically computed. Results The distribution of alleles was significantly different between two groups.The frequencies of ＊0301,＊0401,＊0601,＊0604/5/6/7,＊0302 in EH group were significantly higher than those in control group （P〈0.01 or P〈0.05）.The frequencies of ＊0501,＊0602,＊0603/8,＊0606,＊0402,＊0604/5/6/8 in EH group were significantly lower than those in control group （P〈0.01 or P〈0.05）.Conclusion In Ningxia Hui population,allele DQB1＊0301,＊0401,＊0601,＊0604/5/6/7 and ＊0302 might be danger factors,while ＊0501,＊0602,＊0603/8,＊0606,＊0402 and ＊0604/5/6/8 might be resistive factors of EH.

关 键 词：HLA抗原 易感性 高血压 

分 类 号：R544.1[医药卫生—心血管疾病] Q75[医药卫生—内科学]