衰减全反射红外光谱法测定拉米夫定晶型Ⅱ的含量  

Determination of Lamivudine Monomorphic Form Ⅱ by ATR-IR

作　　者：叶晓霞[1] 刘茜[1] 杨永健[1] 

机构地区：[1]上海市食品药品检验所,上海201203

出　　处：《中国医药工业杂志》2009年第12期928-930,共3页Chinese Journal of Pharmaceuticals

摘　　要：建立了衰减全反射傅立叶变换红外光谱法测定拉米夫定原药和片剂中晶型Ⅱ的含量。拉米夫定晶型Ⅱ的特征峰(850cm-1)与参比峰(785cm-1)的吸收度比值和晶型Ⅱ的浓度呈良好的线性关系(r=0.9935),平均回收率为101.2%,RSD为1.4%。An attenuated total reflectance-infrared spectroscopy （ATR-IR） method was established for the determination of lamivudine monomorphic form II in lamivudine bulk drug and its tablets. There is a good linearity between the absorption ratio of specific peak （850 cm^-1） and reference peak（785 cm^-1） and the concentration of lamivudine polymorphic form II （r=0.993 5）. The average recovery was 101.2 %, with RSD of 2.5 %.

关 键 词：衰减全反射傅立叶变换红外光谱法 拉米夫定 多晶型 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.33[化学工程—制药化工]