玉米幼芽提取物对大鼠乳腺增生的影响  

Effect of extracts of maize plumule on mammary gland hyperplasia rats

作　　者：唐立刚[1,2] 欧阳五庆[1] 杨东英[2] 刘韵佳[1] 

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100 [2]德州学院生物系,山东德州253023

出　　处：《西北农林科技大学学报（自然科学版）》2009年第12期80-84,共5页Journal of Northwest A&F University(Natural Science Edition)

基　　金：国家科技支撑计划项目(2006BAD04A11)

摘　　要：【目的】探讨玉米幼芽提取物对乳腺增生SD大鼠乳腺组织和血清激素的影响，及其抗乳腺增生的作用机理。【方法】以苯甲酸雌二醇联合黄体酬皮下注射方法．制作乳腺增生大鼠模型56只，随机平均分成7组。将玉米幼芽提取物按剂量0，1．25，2．5．5．10．20，40mg／（kg·d）分别给药．连续20d，用药结束后测定大鼠血清激素水平；显微镜下观察大鼠乳腺组织。【结果】玉水幼芽提取物中，高剂量组明显改善了病变组织的形态，并且可显著降低模型大鼠的卯泡生成素（FSH）、血清雌二醇（E2）和辈酮（T）水平，同时提高了模型大鼠催乳素（PRL）和血清黄体生成素（LH）水平，对血清孕酮（P）变化的影响不大。【结论】2．5～40mg／（kg·d）的富含腺嘌呤类衍生物的玉米幼芽提取物，可有效防止和治疗大鼠的乳腺增生。[Objective] The study was to observe the effects of extracts of maize plumule given in different doses on mammary gland hyperplasia of rats and explore the mechanism for the treatment of mammary gland hyperplasia. [Method] 8 healthy rats were set as normal contrast group Ⅰ 56 model rats were divided into 7 groups（group Ⅱ -group Ⅷ ）,and the model of mammary gland hyperplasia was made by hypodermic injection of oestradiol benzoate and progesterone. Model groups（ Ⅲ -Ⅶ ） were intragastrically administered with 0,1.25, 2.5, 5, 10, 20, 40 mg/（kg · d） gradient doses maize plumule extracts. Then the length and diameter of nipples were measured, and the sex hormone of all groups checked. And the slides of mammary glands were observed by microscopic examination. [Result] After drugs interference, mediumdose groups and high-dose groups（ Ⅴ -- Ⅶ ） showed the mend of the mammary glands shapes and pathological tissue in vivo（P〈0.01）） ;Extracts of maize plumule remarkably depressed the level of FSH,E2 and T, and raised the level of PRL and LH（P〈0.01） in Ⅴ -Ⅷ groups,but P was steady. [Conclusion] 2. 5-40 mg/（kg · d） maize plumule extracts with abundant adenine derivatives conld effectively prevent and treat hyperplasia of mammary gland.

关 键 词：玉米幼芽提取物 乳腺增生 氧化损伤 大鼠 

分 类 号：S857.26[农业科学—临床兽医学] R965.1[农业科学—兽医学]